1,923 results found
    1. Neuroscience

    A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments

    Gabriel Loewinger, Erjia Cui ... Francisco Pereira
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Superior colliculus drives stimulus-evoked directionally biased saccades and attempted head movements in head-fixed mice

    Sebastian H Zahler, David E Taylor ... Evan H Feinberg
    Mouse gaze shifts are unexpectedly flexible.
    1. Developmental Biology
    2. Cancer Biology

    Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

    Denise Ragusa, Chun-Wai Suen ... Cristina Pina
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Inadequate
    1. Neuroscience

    Accelerated signal propagation speed in human neocortical dendrites

    Gáspár Oláh, Rajmund Lákovics ... Gábor Tamás
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Chromosomes and Gene Expression

    MagIC-Cryo-EM: Structural determination on magnetic beads for scarce macromolecules in heterogeneous samples

    Yasuhiro Arimura, Hide A Konishi, Hironori Funabiki
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain

    Eva M García-Cuesta, Pablo Martínez ... Mario Mellado
    In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.
    1. Neuroscience

    How relevant is the prior? Bayesian causal inference for dynamic perception in volatile environments

    David Meijer, Roberto Barumerli, Robert Baumgartner
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology

    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in obesity

    Dan Wu, Venkateswararao Eeda ... Weidong Wang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

    Anil Kumar Vijjamarri, Xiao Niu ... Alan G Hinnebusch
    The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

    Georgia M Cook, Katherine Brown ... Ian Brierley
    Combining ribosome profiling and RNA sequencing illuminates novel features of porcine reproductive and respiratory syndrome virus gene expression, including the regulation of polyprotein stoichiometry through temporal modulation of ribosomal frameshifting and the synthesis of non-canonical transcripts.
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