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    1. Epidemiology and Global Health

    Local human movement patterns and land use impact exposure to zoonotic malaria in Malaysian Borneo

    Kimberly M Fornace, Neal Alexander ... Chris Drakeley
    Local human movement into mosquito habitats around forest edges intensifies interactions between pathogens, insects and people, increasing exposure risks to the zoonotic malaria Plasmodium knowlesi in Malaysian Borneo.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release

    Jeffrey T Lock, Ian Parker
    Cell-wide Ca2+ signals that regulate numerous cellular functions comprise dual Ca2+ release modes through IP3 receptors, punctate transients mediated by clustered receptors and spatiotemporally diffuse release through functionally distinct receptors.
    1. Microbiology and Infectious Disease

    Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

    Eleanor Gaunt, Helen M Wise ... Peter Simmonds
    Mutants of influenza A virus with increased CpG dinucleotide frequencies show restricted replication and reduced or absent pathogenicity, and powerful host innate and adaptive responses to infection that confer immunity to re-infection.
    1. Cell Biology

    ALKBH7 mediates necrosis via rewiring of glyoxal metabolism

    Chaitanya A Kulkarni, Sergiy M Nadtochiy ... Paul S Brookes
    Multi-omics reveals that Alkb homolog 7 (ALKBH7), α mitochondrial alpha-ketoglutarate dioxygenase of unclear function, regulates glyoxal metabolism, which may explain its role in necrosis and heart attack.
    1. Neuroscience

    Mouse color and wavelength-specific luminance contrast sensitivity are non-uniform across visual space

    Daniel J Denman, Jennifer A Luviano ... R Clay Reid
    Mice can detect changes in hue independent of luminance, with differing sensitivity to hue and luminance in different parts of visual space.
  1. Early-Career Advisory Group: Election results 2021

    The election of five new members will help ECAG in its efforts to reform research communication and research culture.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Blood-brain barrier-restricted translocation of Toxoplasma gondii from cortical capillaries

    Gabriela C Olivera, Emily C Ross ... Antonio Barragan
    The invasion of Toxoplasma to the CNS across cortical capillaries is restricted by the integrity of the blood-brain barrier (BBB) and exacerbated by the inflammatory response.
    1. Computational and Systems Biology
    2. Neuroscience

    Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model

    Daniel B Dorman, Joanna Jędrzejewska-Szmek, Kim T Blackwell
    Inhibition enhances the spatial specificity of high calcium influx for cooperatively stimulated synapses, suggesting that inhibitory inputs may regulate both synapse-specific and heterosynaptic plasticity to support learning and memory.
    1. Ecology

    Lowland plant arrival in alpine ecosystems facilitates a decrease in soil carbon content under experimental climate warming

    Tom WN Walker, Konstantin Gavazov ... Jake M Alexander
    Uphill migrations of lowland plants into warming alpine ecosystems may yield a positive climate feedback by accelerating soil microbial respiration and decreasing soil carbon content.
    1. Neuroscience

    Microglial calcium signaling is attuned to neuronal activity in awake mice

    Anthony D Umpierre, Lauren L Bystrom ... Long-Jun Wu
    Microglial processes engage calcium signaling in response to hyper- or hypo-active shifts in neuronal activity.