The organization of layered/laminated axon projections in specific regions of the fruitfly central brain is regulated by short-range repulsive guidance and is critical for local inhibitory circuit formation and function.
Threonine promotes sleep via down-regulation of metabotropic GABA transmission in the ellipsoid body R2 neurons that generate homeostatic sleep drive in Drosophila.
Development of imaging methods to capture neural activity and structure through the intact cuticle using 2-photon and 3-photon excitation in the genetic model organism, Drosophila melanogaster.
Daniel Turner-Evans, Stephanie Wegener ... Vivek Jayaraman
A distinctive recurrent network motif in the Drosophila central brain enables neurons that encode angular velocity to shift population activity in compass neurons, thereby updating their heading representation whenever the fly turns.
SIMC1 and SLF1 bind exclusively to SLF2 to form two separate complexes that direct the human SMC5/6 complex to its antiviral defense or DNA lesion repair activities.
Timothy A Currier, Andrew MM Matheson, Katherine I Nagel
Electrophysiology identifies a population of fan-shaped body neurons that encode airflow in two directions relative to the fly midline and whose silencing disrupts proper orientation to airflow.
In teleost fishes, the independent evolution of electrosensory systems was repeatedly associated with evolutionary changes in brain region scaling that were independent of changes in brain–body allometry.
Sejal Davla, Gregory Artiushin ... Donald J van Meyel
Drosophila astrocytes regulate the homeostatic response to sleep need and express the AANAT1 enzyme that limits brain accumulation of serotonin and dopamine caused by overnight sleep deprivation.
Vincent Croset, Christoph D Treiber, Scott Waddell
Sequencing mRNA from thousands of single cells from the Drosophila brain highlights the extent of cellular diversity and reveals co-expression of specific neuropeptides with particular fast-acting neurotransmitters and monoamines.
