570 results found
    1. Developmental Biology

    Murine blastocysts generated by in vitro fertilization show increased Warburg metabolism and altered lactate production

    Seok Hee Lee, Xiaowei Liu ... Paolo F Rinaudo
    In vitro fertilization-conceived murine embryos show evidence of oxidative and metabolic stress with alteration in lactic acid metabolism.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Metabolic memory of Δ9-tetrahydrocannabinol exposure in pluripotent stem cells and primordial germ cells-like cells

    Roxane Verdikt, Abigail A Armstrong ... Patrick Allard
    Exposure of embryonic stem cells to physiological concentrations of Δ9-THC remodels cellular metabolism across differentiation.
    1. Cell Biology

    Cellular hallmarks reveal restricted aerobic metabolism at thermal limits

    Aitana Neves, Coralie Busso, Pierre Gönczy
    Cellular hallmarks of thermal limits are evolutionarily conserved in nematodes, and changes in surface to volume ratio reflect restricted aerobic metabolism at these limits.
    1. Developmental Biology

    Glycolytic flux-signaling controls mouse embryo mesoderm development

    Hidenobu Miyazawa, Marteinn T Snaebjornsson ... Alexander Aulehla
    The functional link between glycolytic flux, cell signalling and mesoderm patterning is investigated in mouse embryo.
    1. Cancer Biology
    2. Cell Biology

    MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect

    Nataly Shtraizent, Charles DeRossi ... Jaime Chu
    Mannose phosphate isomerase is a metabolic enzyme regulating cell survival in both embryonic and cancer cells.
    1. Cell Biology
    2. Developmental Biology

    Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea

    James DB O'Sullivan, Thomas S Blacker ... Zoe F Mann
    Distinct metabolic states coupled with differing morphogen levels regulate HC morphology along the tonotopic axis of the developing chick auditory organ.
    1. Developmental Biology
    2. Medicine

    Vertical transmission of maternal DNA through extracellular vesicles associates with altered embryo bioenergetics during the periconception period

    David Bolumar, Javier Moncayo-Arlandi ... Felipe Vilella
    In vitro analyses reveal how vertical DNA transmission from the mother to the pre-implantation embryo via endometrial extracellular vesicles can impact embryo bioenergetics.
    1. Ecology

    Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis

    John A Burns, Huanjia Zhang ... Ryan Kerney
    The endosymbiosis between an alga and the spotted salamander shows several parallels to invertebrate-algal symbioses as well as to pathogen associations in vertebrate animals.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success

    Christoph Heier, Oskar Knittelfelder ... Ronald P Kühnlein
    An ancestral enzyme tailors allocation of essential lipid resources to the progeny and connects maternal and embryonic sterol metabolism for reproductive success.
    1. Developmental Biology
    2. Genetics and Genomics

    Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition

    Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
    Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.

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