The gene Odd-paired is a late-acting regulator of zygotic gene expression, functioning coordinately with Zelda to influence chromatin accessibility and affecting genes expressed along both axes of Drosophila embryos.
Lineage specification and commitment are synchronized in the developing trophectoderm lineage of the mouse embryo, but are asynchronous events in the maturing inner cell mass, revealing a window of plasticity in this lineage.
At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
Following fertilization, the pioneering transcription factors GAGA factor (GAF) and Zelda are independently required to reprogram the zygotic genome of Drosophila and activate the first wave of gene expression.
In early Drosophila embryos, histone H2Av continuously exchanges between cytoplasmic lipid droplets, a process that modulates H2Av import into nuclei and constitutes a novel post-translational strategy to regulate nuclear H2Av levels.
Primed Track is an image analysis tool that allows for computational correction of drifting specimen to enable accurate lineage tracing of mammalian pre-implantation development even for larger imaging time intervals.