2,493 results found
    1. Developmental Biology
    2. Neuroscience

    Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

    Baruch Haimson et al.
    Spinal dI2 interneurons relay peripheral and intraspinal feedback to premotor networks in the spinal cord and the cerebellum to ensure the stability of bipedal stepping.
    1. Cell Biology
    2. Neuroscience

    Glycolytic preconditioning in astrocytes mitigates trauma-induced neurodegeneration

    Rene Solano Fonseca et al.
    Promoting a Warburg-like shift in astrocytic metabolism through reduced mitochondrial electron transport accommodates the energetic burden caused by brain trauma without overwhelming cellular respiration and redox to salvage dopaminergic neurons.
    1. Cell Biology
    2. Developmental Biology

    Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT

    Spencer R Katz et al.
    Melanin staining for micro-CT imaging, using a novel application of ionic silver deposition, enables qualitative and quantitative 3D analysis of zebrafish pigmentation and reveals subtle phenotypes missed by light microscopy.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

    Arantxa Cebrian-Silla et al.
    Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.
    1. Neuroscience

    Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

    Silvia Leon et al.
    The transcription factor Nhlh2 is a marker of arcuate Kiss1 neurons in adulthood that activates the promotor activity of Kiss1 and Tac3 genes and controls puberty onset and the response of KNDy neurons to leptin in male mice.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

    Suhong Sun et al.
    Adult cochlear supporting cells (SCs) are plastic and respond to ectopic Ikzf2 and Atoh1, and hair cell damage by up-regulating HC and down-regulating their endogenous SC genes.
    1. Genetics and Genomics
    2. Neuroscience

    Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function

    Sonia Coni et al.
    A decrease of the type 2 myotonic dystrophy gene product CNBP causes an impairment of polyamine metabolism and locomotor dysfunction that can be reverted with polyamine supplementation.
    1. Structural Biology and Molecular Biophysics

    The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

    Vivek Garg et al.
    A comprehensive functional analysis of mitochondrial Ca2+ uniporter (MCU) demonstrates that the auxiliary MICU subunits potentiate Ca2+ transport via MCU.

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