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    1. Stem Cells and Regenerative Medicine

    Embryonic origin of adult stem cells required for tissue homeostasis and regeneration

    Erin L Davies et al.
    Anarchic, cycling piwi-1+ embryonic cells gives rise to neoblasts, pluripotent stemcells required for development of all organ systems during S. mediterranea embryogenesis, as well as the maintenance andregeneration of tissues during adulthood.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters

    Ryo Nabeshima et al.
    Fam60a, a component of the Sin3a complex, is required for embryonic development and regulates methylation at a subset of gene promoters.
    1. Developmental Biology
    2. Genetics and Genomics

    Zygotic gene activation in the chicken occurs in two waves, the first involving only maternally derived genes

    Young Sun Hwang et al.
    In Aves, the first wave of transcription is derived exclusively from the maternal genome.
    1. Chromosomes and Gene Expression

    Conserved noncoding transcription and core promoter regulatory code in early Drosophila development

    Philippe J Batut, Thomas R Gingeras
    Gene expression timing during Drosophila development is specified by multiple classes of RNA polymerase II core promoters, and the embryonic transcriptome includes thousands of evolutionarily conserved long noncoding RNAs.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells

    Hamish W King, Robert J Klose
    The chromatin remodeller BRG1 is recruited to pluripotency-associated gene regulatory elements by the pioneer transcription factor OCT4 to support further transcription factor binding and gene regulation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

    Joel Hrit et al.
    The epigenetic regulator TET1 is regulated by the nutrient-sensing enzyme OGT in vitro and in cells.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development

    Jan J Zylicz et al.
    Silencing of gene regulatory elements by modifications of DNA-bound proteins promotes the progression of early mouse development.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    GUY1 confers complete female lethality and is a strong candidate for a male-determining factor in Anopheles stephensi

    Frank Criscione et al.
    Evidence that the small GUY1 protein is a strong candidate for being a male-determining factor is provided via the establishment of Guy1 transgenic lines of mosquitoes that confer complete and stable female lethality.
    1. Developmental Biology
    2. Evolutionary Biology

    Logics and properties of a genetic regulatory program that drives embryonic muscle development in an echinoderm

    Carmen Andrikou et al.
    A gene regulatory network model provides a simplified explanation of the molecular interactions that orchestrate muscle development in the sea urchin embryo.
    1. Developmental Biology
    2. Evolutionary Biology

    The mlpt/Ubr3/Svb module comprises an ancient developmental switch for embryonic patterning

    Suparna Ray et al.
    mille-pattes micropeptides have conserved function in insect embryonic patterning together with transcription factor Shaven-baby and ubiquitin ligase Ubr3, except in flies wherein restoring broad embryonic Svb expression restores patterning potency.