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    1. Developmental Biology

    Position- and Hippo signaling-dependent plasticity during lineage segregation in the early mouse embryo

    Eszter Posfai et al.
    Lineage specification and commitment are synchronized in the developing trophectoderm lineage of the mouse embryo, but are asynchronous events in the maturing inner cell mass, revealing a window of plasticity in this lineage.
    1. Developmental Biology

    Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

    Bechara Saykali et al.
    At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
    1. Chromosomes and Gene Expression

    GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

    Marissa M Gaskill et al.
    Following fertilization, the pioneering transcription factors GAGA factor (GAF) and Zelda are independently required to reprogram the zygotic genome of Drosophila and activate the first wave of gene expression.
    1. Developmental Biology

    Addressing the ethical issues raised by synthetic human entities with embryo-like features

    John Aach et al.
    Guidelines governing research into embryos need to be updated in a way that reflects the moral status of synthetic human entities generated using the methods of synthetic biology.
    1. Cell Biology
    2. Developmental Biology

    Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in Drosophila embryos

    Matthew Richard Johnson et al.
    In early Drosophila embryos, histone H2Av continuously exchanges between cytoplasmic lipid droplets, a process that modulates H2Av import into nuclei and constitutes a novel post-translational strategy to regulate nuclear H2Av levels.
    1. Stem Cells and Regenerative Medicine

    Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

    Sophie M Morgani et al.
    Micropatterned differentiation of mouse pluripotent stem cells gives rise to regionally distinct cell types arising in embryos at gastrulation.
    1. Cell Biology
    2. Developmental Biology

    Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

    Amanda D Yzaguirre et al.
    Ras-GAP activity suppresses the hemogenic potential of the embryonic heart.
    1. Developmental Biology

    Primed Track, high-fidelity lineage tracing in mouse pre-implantation embryos using primed conversion of photoconvertible proteins

    Maaike Welling et al.
    Primed Track is an image analysis tool that allows for computational correction of drifting specimen to enable accurate lineage tracing of mammalian pre-implantation development even for larger imaging time intervals.
    1. Cell Biology
    2. Developmental Biology

    Early asymmetric cues triggering the dorsal/ventral gene regulatory network of the sea urchin embryo

    Vincenzo Cavalieri, Giovanni Spinelli
    During early embryogenesis of the sea urchin, asymmetrical positioning of the dorsal/ventral organizer relies upon the suppression of organizer activities in dorsal blastomeres by the Hbox12 homeodomain-containing repressor.
    1. Developmental Biology

    ZP4 confers structural properties to the zona pellucida essential for embryo development

    Ismael Lamas-Toranzo et al.
    Zona pellucida requires ZP4 protein to efficiently protect the developing embryo during in vivo pre-implantation development.