Bats' uniquely robust innate antiviral immune defenses select for faster transmitting viruses likely to generate extreme virulence upon spillover to secondary hosts with immune systems divergent from those of bat.
Pathogen natural history, epidemiological knowledge, human behavior and epidemic progression determine whether symptom screening and questionnaires are effective barriers to geographic spread of infection by travelers.
Predicting the pandemic potential of influenza viruses from genetic sequence data could transform pandemic risk assessment but progress towards this goal will require the integration of experimental work, computational tools, and virus surveillance.
When coupling between STN spikes and cortical gamma oscillations was strong, subsequent movement was initiated earlier, independent of changes in mean firing rates, demonstrating the importance of relative spike timing.
Phosphorylated tau was related to a loss of structural stability in medial temporal lobe connectivity, and this loss of stability moderated the relationship between phosphorylated tau accumulation and memory decline.