531 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

    Wilson Wong et al.
    The molecular mechanism behind how emetine inhibits the ribosome of the human malaria parasite, along with structural details of the complex formed, is revealed at high resolution using cryo-electron microscopy.
    1. Cell Biology

    Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

    Abigail Buchwalter et al.
    Emerin, a protein that plays key roles in nuclear organization, can be dynamically degraded in response to environmental stimuli such as ER stress.
    1. Neuroscience

    Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta

    Emelyne Teo et al.
    Metabolic defects following expression of Aβ1-42 in nematode neurons are partially caused by inactivation of alpha-ketoglutarate dehydrogenase and can be rescued by Metformin.
    1. Biochemistry and Chemical Biology

    RNA-dependent RNA targeting by CRISPR-Cas9

    Steven C Strutt et al.
    Divergent Cas9 enzymes direct site-specific single-stranded RNA cleavage, reducing infection by RNA phage in vivo and enabling programmable, PAM-independent repression of gene expression in bacteria.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Puromycin reactivity does not accurately localize translation at the subcellular level

    Syed Usman Enam et al.
    Methods that use puromycin to localize active translation do not actually detect the site of translation.
    1. Epidemiology and Global Health

    Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

    David W Eyre et al.
    Risk factors for SARS-CoV-2 infection in healthcare workers included caring for Covid-19 patients, Black or Asian ethnicity, and Covid-19-positive household contacts, whereas a bundle of PPE-related measures protected ICU staff.
  1. Meeting Report: Improving research culture

    Mark Patterson, Executive Director at eLife reflects on a recent meeting at the Royal Society.
  2. Meeting report: Visions and versions and the future of peer review

    Mark Patterson shares some perspectives after the recent ASAPbio meeting on Transparency, Recognition, and Innovation in Peer Review in the Life Sciences.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity

    Welkin H Pope et al.
    A continuum of genome relationships is discovered through comparative genomics of 627 sequenced mycobacteriophages isolated and characterized in an integrated research/education initiative.

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