1,397 results found
    1. Neuroscience

    Optogenetically induced low-frequency correlations impair perception

    Anirvan Nandy et al.
    Low-frequency correlations among neurons in monkey visual area V4 impair the animal's ability to perform an attention-demanding task, suggesting a causal role of these fluctuations in perception.
    1. Neuroscience

    AMPAR/TARP stoichiometry differentially modulates channel properties

    Federico Miguez-Cabello et al.
    A variable number of auxiliary subunit molecules (TARPs) accompanying AMPARs have a differential impact on channel behavior showing also striking differences between AMPAR subtypes.
    1. Neuroscience

    Alterations in the amplitude and burst rate of beta oscillations impair reward-dependent motor learning in anxiety

    Sebastian Sporn et al.
    State anxiety alters the dynamics of beta oscillations during reward-dependent motor learning, thereby impairing proper updating of motor predictions when learning in unstable environments.
    1. Cell Biology
    2. Neuroscience

    Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory

    Yang Niu et al.
    SNX6 regulates the distribution of a protein called Homer1b/c to distal dendrites, enabling the latter to stabilize the synapses and thereby support memory formation.
    1. Chromosomes and Gene Expression

    Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

    Mélanie Criqui et al.
    Cell lineage tracing and biochemical analysis of cell fate during murine stem cell differentiation demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres that destabilize cell differentiation.
    1. Structural Biology and Molecular Biophysics

    Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE

    Yao Li et al.
    A multidisciplinary platform featured by patient-derived RPEs is established to study the disease-causing mechanisms of BEST1 mutations, and demonstrates gene-supplemented rescue of the mutation-caused deficiency in Ca2+-dependent Cl- current in human RPE.
    1. Neuroscience

    Neuromodulation of excitatory synaptogenesis in striatal development

    Yevgenia Kozorovitskiy et al.
    Protein kinase A regulates the rapid, activity-dependent genesis of excitatory synapses during striatal development.
    1. Neuroscience

    The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory

    Leanne J M Schmitz et al.
    Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics of hippocampal AMPARs, and is necessary for synaptic plasticity and memory recall.
    1. Neuroscience

    Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties

    Paul Farrow et al.
    Three AMPAR interacting proteins – namely CKAMP39, CKAMP52 and CKAMP59 – together with the previously characterized CKAMP44, constitute a new family of auxiliary subunits that are distinct from other families of AMPAR interacting proteins.
    1. Cell Biology
    2. Neuroscience

    Synaptic activity regulates AMPA receptor trafficking through different recycling pathways

    Ning Zheng et al.
    There are at least two separate pathways for AMPA receptor recycling, which are regulated by synaptic activity.

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