2,396 results found
    1. Genetics and Genomics
    2. Evolutionary Biology

    Current CRISPR gene drive systems are likely to be highly invasive in wild populations

    Charleston Noble, Ben Adlam ... Martin A Nowak
    If released in the wild, current CRISPR-based gene drive systems designed to alter populations could spread much farther than intended, despite the evolution of drive resistance.
    1. Computational and Systems Biology
    2. Ecology

    Emergent regulation of ant foraging frequency through a computationally inexpensive forager movement rule

    Lior Baltiansky, Guy Frankel, Ofer Feinerman
    Rather than complex decisions, it is the motion of individuals that allows for collective foraging regulation in ant colonies.
    1. Evolutionary Biology

    Can Hamilton’s rule be violated?

    Matthijs van Veelen
    Hamilton's rule can be violated when costs and benefits of cooperation are defined using the counterfactual method, and when they depend on the cooperation of others.
    1. Computational and Systems Biology
    2. Neuroscience

    Meta-Research: Dataset decay and the problem of sequential analyses on open datasets

    William Hedley Thompson, Jessey Wright ... Russell A Poldrack
    Open data provides an opportunity to perform new analyses on preexisting data, but trade-offs are required to limit an increase in false positives.
    1. Neuroscience

    A neural network model of hippocampal contributions to category learning

    Jelena Sučević, Anna C Schapiro
    A neural network model of the hippocampus exhibits a division of labor across its two main pathways during category learning, with one pathway specializing in extracting systematic category information and another in encoding arbitrary details.
    1. Computational and Systems Biology
    2. Neuroscience

    Trading mental effort for confidence in the metacognitive control of value-based decision-making

    Douglas G Lee, Jean Daunizeau
    Intra-individual variability in choice, response time, subjective effort, confidence, and choice-induced preference change and certainty gain is explained by a cost–benefit model of cognitive resource allocation.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A Y-chromosome shredding gene drive for controlling pest vertebrate populations

    Thomas AA Prowse, Fatwa Adikusuma ... Joshua V Ross
    A Y-chromosome shredding gene drive that depletes the pool of XY males and effects mate limitation could be a viable tool for vertebrate pest control.
    1. Evolutionary Biology

    The evolution of manipulative cheating

    Ming Liu, Stuart Andrew West, Geoff Wild
    By considering a new form of social cheat strategy, arms-races-like dynamics between coevolving selfish traits could emerge from the tragedy of the commons and help explain the variations in cheating levels observed in many microbes and eusocial insects.
  1. Meta-Research: Questionable research practices may have little effect on replicability

    Rolf Ulrich, Jeff Miller
    Although questionable research practices inflate false positive rates, they have little effect on replicability because they also increase power.
    1. Neuroscience

    Rate and oscillatory switching dynamics of a multilayer visual microcircuit model

    Gerald Hahn, Arvind Kumar ... Gustavo Deco
    A computer model of the mouse visual cortex shows that local brain circuits are organized as switches whose states are coded as neuronal oscillations with different frequencies.

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