6,304 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding

    Jixin Cui et al.
    Fam20A, a pseudokinase involved in the formation of tooth enamel, binds ATP in an unexpected orientation.
    1. Biochemistry and Chemical Biology

    A secretory kinase complex regulates extracellular protein phosphorylation

    Jixin Cui et al.
    A pseudokinase in the secretory pathway, Fam20A, activates the real Golgi casein kinase, Fam20C, via a unique mechanism that is lost in human diseases.
    1. Biochemistry and Chemical Biology

    Protein Kinases: What is the point of pseudokinases?

    Saravanan Raju, Andrey S Shaw
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  1. Point of view: Motivating participation in open science by examining researcher incentives

    Sarah E Ali-Khan et al.
    A survey of researchers at the Montreal Neurological Institute and Hospital provides insights into the challenges and opportunities involved in adopting an open science policy across an entire patient-oriented academic institution.
  2. Peer Review: Searching for the one

    Helga Groll
    The views of peers are important when applying for a faculty position, but so are research plans and being a good 'fit'.
    1. Developmental Biology
    2. Evolutionary Biology

    Multicellularity: The evolution of gene regulation

    Veronica Hinman, Gregory Cary
    The gene regulation mechanisms necessary for the development of complex multicellular animals have been found in sponges.
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  3. Point of View: What does it take to recruit and retain senior women faculty?

    Fiona M Watt
    eLife deputy editor Fiona M Watt recounts some of her personal experiences as a senior female academic in a male-dominated environment.
    1. Neuroscience

    Neuroscience: Multitasking on the run

    Mary E Hatten, Stephen G Lisberger
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  4. Tutorial: How to draw the line in biomedical research

    Lisa Huang et al.
    When analysing the data in a two-dimensional scatter plot, researchers should consider plotting the three regression lines that can be calculated for such a plot.

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