Encapsulin-associated ferritin proteins form metal-dependent decamers that are active as ferroxidase enzymes, but require encapsulation to form an iron store.
Heme accumulation is toxic, but deficiency of the heme transporter HRG1/SLC48A1 causes heme sequestration and crystallization into hemozoin within enlarged lysosomes of macrophages, thereby conferring heme tolerance to mammals.
A protein-bounded organelle-like compartment from Synechococcus elongatus PCC 7942 is upregulated under sulfur starvation and contains a cysteine desulfurase cargo enzyme.
Cuticulosomes are organelles found in the hair cells of birds that are composed of ferritin nanoparticles, form rapidly after hatching by the fusion of vesicular structures, and may play an indirect role in magnetic sensation.
Magnetothermal neuromodulation providing quick, tetherless, precise on and off switching of neurons deep in the brain of freely moving animals is orthogonal to optogenetics and a breakthrough in remote modulation techniques.
