10 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments

    Didi He et al.
    Encapsulin-associated ferritin proteins form metal-dependent decamers that are active as ferroxidase enzymes, but require encapsulation to form an iron store.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Large protein organelles form a new iron sequestration system with high storage capacity

    Tobias W Giessen et al.
    An alternative iron storage system based on a 9.6 megadalton microbial protein compartment is able to sequester and store large amounts of iron.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolution of the head-trunk interface in tetrapod vertebrates

    Elizabeth M Sefton et al.
    Both gill musculature and the evolutionarily conserved cucullaris muscle are derived from unsegmented mesoderm adjacent to the first 3 somites, extending the posterior limit of cranial mesoderm.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Competing scaffolding proteins determine capsid size during mobilization of Staphylococcus aureus pathogenicity islands

    Altaira D Dearborn et al.
    Cryo-electron microscopy and genetics show how Staphylococcus aureus pathogenicity island 1 hijacks the assembly pathway of a helper phage for its own propagation.
    1. Cancer Biology

    Replication Study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

    Jeewon Kim et al.
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but other parts could not be interpreted.
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Many-molecule encapsulation by an icosahedral shell

    Jason D Perlmutter et al.
    Computational and theoretical models reveal mechanisms by which protein compartments assemble around enzymes and reagents to facilitate reactions in bacteria, allowing the identification of strategies for reengineering such compartments as customizable nanoreactors.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Recurrent turnover of senescent cells during regeneration of a complex structure

    Maximina H Yun et al.
    Senescent cells are recurrently induced during limb regeneration in salamanders and subsequently eliminated by a highly efficient mechanism of macrophage-dependent surveillance.
    1. Immunology and Inflammation

    Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

    Naresh S Redhu et al.
    A detailed time-series analysis reveals that the interleukin-10 receptor prevents susceptibility to microbiota-driven colonic inflammation that emerges at the time of weaning by directly inhibiting the acquisition of a pro-inflammatory intestinal macrophage phenotype.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    A new topology of the HK97-like fold revealed in Bordetella bacteriophage by cryoEM at 3.5 Å resolution

    Xing Zhang et al.
    Cryo electron microscopy and structure-based mutagenesis reveal that the bacteriophage BPP-1 contains two of the three major recognized viral folds, one of which exhibits a new topology.
    1. Neuroscience

    Environmental stimuli shape microglial plasticity in glioma

    Stefano Garofalo et al.
    The microenvironment of brain tumors can be modulated by in vivo conditions that change the brain levels of BDNF and IL-15, with effects on innate immune cell activation.

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