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    1. Immunology and Inflammation

    Atypical memory B-cells are associated with Plasmodium falciparum anemia through anti-phosphatidylserine antibodies

    Juan Rivera-Correa, Maria Sophia Mackroth ... Ana Rodriguez
    The association of atypical memory B-cells and autoimmune antibodies (anti-phosphatidylserine) with hemoglobin levels in malaria patients uncovers a novel mechanism for the human malaria-induced anemia previously identified in mice.
    1. Epidemiology and Global Health

    Global variation in force-of-infection trends for human Taenia solium taeniasis/cysticercosis

    Matthew A Dixon, Peter Winskill ... María-Gloria Basáñez
    Marked geographical heterogeneity in global Taenia solium transmission rates indicate the need for setting-specific intervention strategies to achieve the WHO NTD 2021-2030 roadmap milestones for T. solium.
    1. Epidemiology and Global Health

    Model-based spatial-temporal mapping of opisthorchiasis in endemic countries of Southeast Asia

    Ting-Ting Zhao, Yi-Jing Feng ... Ying-Si Lai
    High-resolution risk estimates of opisthorchiasis were produced in major endemic countries of Southeast Asia, providing valuable information for guiding disease control and serving as a baseline for future progress assessment.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization

    Wiebke Nahrendorf, Philip J Spence ... Jean Langhorne
    A novel mouse model of immunization against Plasmodium chabaudi involving infectious mosquito bites and drug-treatment elicits protection against blood-stage malaria parasites, and shows that protection is not necessarily life cycle stage-specific.
    1. Immunology and Inflammation

    A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses

    Suresh Pallikkuth, Sidhartha Chaudhury ... Savita Pahwa
    Circulating T follicular helper cells appear to be a promising biomarker candidate for monitoring vaccine efficacy in malaria vaccine trials.
    1. Ecology
    2. Epidemiology and Global Health

    Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence

    Cara E Brook, Mike Boots ... Anieke van Leeuwen
    Bats' uniquely robust innate antiviral immune defenses select for faster transmitting viruses likely to generate extreme virulence upon spillover to secondary hosts with immune systems divergent from those of bat.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Impact of the scale-up of piped water on urogenital schistosomiasis infection in rural South Africa

    Frank Tanser, Daniel K Azongo ... Christopher Appleton
    Scale-up of safe water supplies decreases a child's risk of urogenital schistosomiasis infection by eight-fold in a typical rural African population.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri

    Thomas R Connor, Clare R Barker ... Nicholas R Thomson
    Shigella flexneri, globally the most frequent cause of bacterial dysentery, is far more diverse, and has caused disease around the world for far longer than other Shigella species by persisting in local environments over extended timescales.
    1. Epidemiology and Global Health

    Lives saved with vaccination for 10 pathogens across 112 countries in a pre-COVID-19 world

    Jaspreet Toor, Susy Echeverria-Londono ... Katy AM Gaythorpe
    Vaccination activities that occurred before the COVID-19 pandemic, 2000-2019, are estimated to avert 50 million deaths, highlighting the enormous benefits of continued and improving vaccination.
    1. Epidemiology and Global Health
    2. Medicine

    Estimates of the global burden of Japanese encephalitis and the impact of vaccination from 2000-2015

    Tran Minh Quan, Tran Thi Nhu Thao ... Hannah Clapham
    Modelling analysis reveals the burden of Japanese Encephalitis is greater than previously thought, and although vaccination has reduced burden, there are remaining places with a great need for vaccination.