In yeast, a fluorescent vacuolar cargo departs from Golgi cisternae early in the TGN stage of maturation, and traffic from prevacuolar endosomes to the vacuole apparently involves a kiss-and-run mechanism.
Analysis of rats carrying the microglia gene and Alzheimer risk factor Trem2R47H variant shows increased glutamatergic transmission via supraphysiological TNF-α brain concentrations, linking a microglia pathogenic variant to neuronal dysfunction.
The lipid kinase VPS34 complexes I and II are both activated by unsaturation of substrate and non-substrate lipids, curvature, electrostatics and polyphosphoinositides, which play roles in localisation and cellular function.
Infection experiments in ferrets reveal swine influenza viruses need their hemagglutinin antigen to become stabilized for transmissibility, adding a new property to consider when triaging field isolates for pandemic potential.
The reduced ability of Drosophila imaginal discs to regenerate as they mature can be explained by the silencing of damage-responsive enhancers that regulate expression of genes required for regeneration.