2,946 results found
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling

    Jinrui Dong et al.
    IL6ST (gp130) binding proteins, such as HyperIL6, promote liver regrowth in a STAT3-indpependent manner through competitive inhibition of anti-regenerative IL11 signaling.
    1. Cell Biology
    2. Developmental Biology

    Whole-organism 3D quantitative characterization of zebrafish melanin by silver deposition micro-CT

    Spencer R Katz et al.
    Melanin staining for micro-CT imaging, using a novel application of ionic silver deposition, enables qualitative and quantitative 3D analysis of zebrafish pigmentation and reveals subtle phenotypes missed by light microscopy.
    1. Stem Cells and Regenerative Medicine

    Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells

    Diptiman Chanda et al.
    Lung stem cell niche aging is associated with altered bioenergetics, metabolic dysfunction, and senescence of mesenchymal stromal cells that restricts 3D organoid, or alveolosphere formation, potentially accounting for reduced regenerative capacity with aging.
    1. Neuroscience

    Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2

    Silvia Leon et al.
    The transcription factor Nhlh2 is a marker of arcuate Kiss1 neurons in adulthood that activates the promotor activity of Kiss1 and Tac3 genes and controls puberty onset and the response of KNDy neurons to leptin in male mice.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Dual expression of Atoh1 and Ikzf2 promotes transformation of adult cochlear supporting cells into outer hair cells

    Suhong Sun et al.
    Adult cochlear supporting cells (SCs) are plastic and respond to ectopic Ikzf2 and Atoh1, and hair cell damage by up-regulating HC and down-regulating their endogenous SC genes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

    Maren Heimhalt et al.
    The inhibitory protein DEPTOR make two widely separated interactions with mTOR that are both necessary for its unique partial mTOR inhibition, and DEPTOR is a more potent inhibitor of mutation- or RHEB-activated mTORC1 than basal mTORC1.
    1. Structural Biology and Molecular Biophysics

    The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

    Vivek Garg et al.
    A comprehensive functional analysis of mitochondrial Ca2+ uniporter (MCU) demonstrates that the auxiliary MICU subunits potentiate Ca2+ transport via MCU.
    1. Cancer Biology
    2. Cell Biology

    Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timing

    Lauren K Williams et al.
    Cytoplasmic bodies sequester important abscission machinery to delay completion of cytokinesis in response to mitotic errors.
    1. Cell Biology
    2. Immunology and Inflammation

    Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

    Janine JG Arts et al.
    Neutrophils use dorsal membrane protrusions of endothelial cells to cross the vascular wall.
    1. Genetics and Genomics
    2. Neuroscience

    Neuronal calmodulin levels are controlled by CAMTA transcription factors

    Thanh Thi Vuong-Brender et al.
    CAMTA transcription factors are evolutionarily conserved regulators of neuronal levels of the major Ca2+ sensor calmodulin.

Refine your results by:

Type
Research categories