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TRPM3 inhibition is identified as a novel mechanism for G-protein βγ subunit signalling.

Osteoblastic PGE2 induces pain and OA progression by Na_V1.8 modification and serves as a potential target multiple skeletal pain and degenerations.

Pharmacological fMRI study provides evidence that learning from the unexpected presence and absence of pain is mediated by different brain systems.

Opioids have distributed effects on the brainstem circuitry that controls breathing, including presynaptic and postsynaptic receptor-mediated inhibition of an excitatory circuit from the dorsolateral pons to the ventrolateral medulla.

The voltage-sensing mechanism of a subfamily of potassium channels is modulated in unconventional ways by an amino acid transporter.

Multiple roles of the auxiliary calcium channel α2δ subunits require proteolytic cleavage of the precursor protein into α2 and δ.

The discovery that opioid neuropeptide neuronal signaling controls feeding behavior in a genetically tractable invertebrate model may help unravel the mechanisms of appetite control in humans.

The locus coeruleus is organised into functional modules with subsets of noradrenergic neurones independently projecting to the spinal cord and prefrontal cortex to exert discrete, antithetical modulatory actions on a range of pain-related behaviours.

Close friend quantity is nonlinearly associated with various mental health and cognitive outcomes in children and could be partly explained by the structure of the social brain and the endogenous opioid system.

Facial expression provides a complementary channel to communicate pain experiences and reflects the activation of brain mechanisms partly distinct from those associated with subjective self-reports of pain.