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    1. Neuroscience

    Strategically managing learning during perceptual decision making

    Javier Masís, Travis Chapman ... Andrew M Saxe
    During perceptual decision making, maximizing total reward in the long term requires trading reward in the short term for a faster improvement in perceptual representations.
    1. Cell Biology
    2. Physics of Living Systems

    De novo identification of universal cell mechanics gene signatures

    Marta Urbanska, Yan Ge ... Jochen Guck
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Microbiology and Infectious Disease

    Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus

    Juan-Carlos García-Betancur, Angel Goñi-Moreno ... Daniel Lopez
    During Staphylococcus aureus infections, bacterial cells bifurcate into distinct, specialized cell types that localize physically in different colonization tissues to simultaneously generate different infection types.
    1. Microbiology and Infectious Disease

    The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2

    Rahul K Suryawanshi, Priyadarshini Jaishankar ... James S Fraser
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology
    2. Neuroscience

    A spatial threshold for astrocyte calcium surge

    Justin Lines, Andres Baraibar ... Alfonso Araque
    In astrocytes, there exists an intrinsic spatial threshold of subcellular calcium levels that triggers an astrocyte calcium surge throughout the cell, demonstrating cellular astrocyte calcium integration of time and space.
    1. Developmental Biology
    2. Neuroscience

    Synapse weakening-induced caspase-3 activity confers specificity to microglia-mediated synapse elimination

    Zhou Yu, Andrian Gutu ... Erin K O’Shea
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Neuroscience

    Efficient sampling and noisy decisions

    Joseph A Heng, Michael Woodford, Rafael Polania
    An efficient coding theory for higher-level cognitive processes reveals that humans efficiently adapt to contextual distributions by economizing on environmental prior information.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

    Matthew C Pahl, Prabhat Sharma ... Andrew D Wells
    The three-dimensional architecture of the genome in distinct cell types predicts genes and regulatory elements involved in cell function and disease.
    1. Genetics and Genomics
    2. Neuroscience

    High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

    Qiaochu Li, Daniel-Cosmin Marcu ... Karl Emanuel Busch
    Chronic excitation of the Caenorhabditis elegans oxygen-sensing neurons alters calcium homeostasis to accelerate the decline of neural plasticity with age.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Bacterial cell cycle control by citrate synthase independent of enzymatic activity

    Matthieu Bergé, Julian Pezzatti ... Patrick H Viollier
    A key enzyme of central energy metabolism, citrate synthase, regulates bacterial cell cycle progression at a very specific stage (S-phase) and independently of its enzymatic activity.