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An alternative method for mapping RNA polymerase II occupancy over the genome provides new insights into the kinetics and molecular mechanism of transcription.

Attention-grabbing tasks produce rapid opioid-mediated analgesia via the descending pain modulation network to alter spinal neuronal activity.

The split mNeonGreen system enables fast and efficient endogenous tagging in human iPSCs and facilitates the study of proteins in human stem cells and differentiated cells by live imaging.

The reconstitution of a functional envelope protein from an extinct hominid retrovirus reveals its receptor and an ancient host defense that may have led to the extinction of the virus.

Bi-allelic tagging enables the biophysical analysis of oncogenic β-catenin genetic variants in Wnt signaling.

Endogenous µ- and δ-opioid receptors do not form stable heterodimers in cholinergic interneurons.

Through associative learning, environmental context can come to exert control over the endogenous opioid system such that it is recruited as a conditioned compensatory response to ongoing painful stimuli in both male and female mice, or in anticipation of a painful stimulus in females.

Gene-editing to repair non-functional transcriptional elements in the endogenous promoter of δ-globin increases overall expression of adult hemoglobin 2 (HbA2), providing proof-of-concept for a therapeutic avenue to treat β-hemoglobinopathies.

Virus infection in mosquitoes initiates a highly discriminatory process in which fragments of viral RNA are reverse transcribed to create DNA copies that serve as templates of small antiviral RNAs.

An ancient integration of an endogenous retroelement in the gene encoding PD-L1 is exapted to generate a soluble form that antagonises the suppressive function of the membrane-bound form.