36 results found
    1. Cell Biology

    circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis

    Minmin Song et al.
    Upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium sponged miR-21–5 p and resulted in upregulation of its target gene, ΔNp63α, which induced transition of EECs to mesenchymal cells.
    1. Developmental Biology

    Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility

    Hatice Duygu Saatcioglu et al.
    Single-cell RNA sequencing of neonatal uterus revealed an Misr2+ endometrial stromal progenitor whose inhibition by ectopic administration of MIS caused uterine hypoplasia and infertility in adulthood.
    1. Developmental Biology

    Oviductal estrogen receptor α signaling prevents protease-mediated embryo death

    Wipawee Winuthayanon et al.
    Cyclic estrogen signaling in oviduct epithelial cells suppresses oviduct luminal protease activity to allow survival and development of preimplantation embryos
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion

    Vicente Perez-Garcia et al.
    BAP1/ASXL is a key regulator of trophoblast invasion during early mouse and human placentation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis

    Xiaodan Ji et al.
    Transcription elongation by the elongation factor P-TEFb promotes the epithelial–mesenchymal transition and metastasis of breast cancer cells, implicating inhibition of this factor as a potential treatment for the late stages of this cancer.
    1. Cell Biology
    2. Cancer Biology

    A kinase-independent function of AKT promotes cancer cell survival

    Igor Vivanco et al.
    The oncogenic potential of the serine threonine kinase AKT is not exclusively dependent on catalytic activity, but also involves the non-catalytic function of the pleckstrin homology domain.
    1. Microbiology and Infectious Disease

    HIV in Women: How HIV exploits T cells in the endometrium

    Marta Rodriguez-Garcia
    Immune cells in the endometrium are targeted by HIV and re-programmed to allow them to survive and spread the virus throughout the body.
    Insight
    Available as:
    • HTML
    • PDF
    1. Computational and Systems Biology
    2. Cancer Biology

    Mitochondrial DNA copy number variation across human cancers

    Ed Reznik et al.
    Many tumors are depleted of mitochondrial DNA; this depletion is associated with changes in gene expression and with the incidence of critical somatic mutations and alterations.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence

    Shou Liu et al.
    ARID1A deficiency in SWI/SNF complex promotes pancreatic tumor development by upregulating ALDH protein levels to effectively reduce cellular reactive oxygen species levels, leading to the significant attenuation of oncogenic KRAS-induced senescence.

Refine your results by:

Type
Research categories