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    1. Cancer Biology

    Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells

    Simone Lieb et al.
    Targeting Werner syndrome helicase might constitute a novel opportunity for the treatment of a clinically defined subset of patients harboring MSI-H/MMR-deficient tumors.
    1. Developmental Biology
    2. Neuroscience

    Transcriptional profiling of mouse peripheral nerves to the single-cell level to build a sciatic nerve ATlas (SNAT)

    Daniel Gerber et al.
    Establishing transcriptional profiles of nerve-inhabitant cells as resource to foster the fundamental understanding of peripheral nerves.
    1. Developmental Biology

    Pregnancy success in mice requires appropriate cannabinoid receptor signaling for primary decidua formation

    Yingju Li et al.
    Cannabinoid signaling is critical for integration of vascular system and uterine decidualization.
    1. Cell Biology
    2. Cancer Biology

    A kinase-independent function of AKT promotes cancer cell survival

    Igor Vivanco et al.
    The oncogenic potential of the serine threonine kinase AKT is not exclusively dependent on catalytic activity, but also involves the non-catalytic function of the pleckstrin homology domain.
    1. Neuroscience

    Upregulation of TRPM3 in nociceptors innervating inflamed tissue

    Marie Mulier et al.
    The expression and function of the cation channel TRPM3 is strongly increased in sensory neurons innervating inflamed tissue, likely contributing to inflammatory hyperalgesia and persistent pain.
    1. Neuroscience

    Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy

    Evelien Van Hoeymissen et al.
    Two mutations in TRPM3 resulting in developmental and epileptic encephalopathies result in a gain-of-channel function, which may lie at the basis of epileptic activity and neurodevelopmental symptoms in the patients.
    1. Cancer Biology
    2. Cell Biology

    TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions

    Nitin H Shirole et al.
    Genetic and molecular analysis of TP53 exon-6 truncating mutations reveal that these mutations, contrary to current belief, promote tumorigenesis and point towards strategies for treating cancers driven by these prevalent mutations.
    1. Developmental Biology

    Oviductal estrogen receptor α signaling prevents protease-mediated embryo death

    Wipawee Winuthayanon et al.
    Cyclic estrogen signaling in oviduct epithelial cells suppresses oviduct luminal protease activity to allow survival and development of preimplantation embryos
    1. Genetics and Genomics

    Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

    Niko Välimäki et al.
    Genetic predisposition to uterine leiomyomas arises from variation at loci for genetic stability and genitourinary development, and in part explains the frequent occurrence of the condition in women with African origin.
    1. Computational and Systems Biology
    2. Cancer Biology

    Mitochondrial DNA copy number variation across human cancers

    Ed Reznik et al.
    Many tumors are depleted of mitochondrial DNA; this depletion is associated with changes in gene expression and with the incidence of critical somatic mutations and alterations.