Endothelin signalling, regulated by changes in neuronal activity associated with experience, influences the number of myelin sheaths formed by individual oligodendrocytes.

The BAR protein endophilin spaces out turns of the dynamin helix, blocking its active conformational change and membrane fission.

The Sac1 phosphatase domain, rather than the proline-rich domain, plays an essential role in synaptojanin activity during endocytosis.

Analyses of knockout mice and a biochemical screen of interacting proteins reveal that exophilin-8 forms a large network of protein interactions to efficiently retain secretory granules beneath the plasma membrane for exocytosis.

Global transcriptome analysis reveals that the transcription factor SOX4 can promote breast tumor development via tumor angiogenesis by promoting paracrine signalling through endothelin-1.

Second-order guidance, a novel mechanism by which an initial guidance cue controls expression of a second guidance receptor, is required for precise refinement of axon trajectories during PNS development.

The presynaptic scaffolding protein Bassoon is involved in regulating neurotransmitter release by controlling synaptic vesicle pool size and vesicular protein turnover through increased ubiquitination and Parkin-dependent autophagy.

The IL-4/IL-4Rα axis directory promotes pathological angiogenesis through communications with bone marrow cells leading to neovascular age-related macular degeneration.

Identifying why statins differ from other major lipid modifiers has revealed a new modifiable target of intervention for cardiovascular disease relevant to both drug development and optimal statin use.