The BAR protein endophilin spaces out turns of the dynamin helix, blocking its active conformational change and membrane fission.

The Sac1 phosphatase domain, rather than the proline-rich domain, plays an essential role in synaptojanin activity during endocytosis.

Analyses of knockout mice and a biochemical screen of interacting proteins reveal that exophilin-8 forms a large network of protein interactions to efficiently retain secretory granules beneath the plasma membrane for exocytosis.

Global transcriptome analysis reveals that the transcription factor SOX4 can promote breast tumor development via tumor angiogenesis by promoting paracrine signalling through endothelin-1.

Second-order guidance, a novel mechanism by which an initial guidance cue controls expression of a second guidance receptor, is required for precise refinement of axon trajectories during PNS development.

Data-driven methods predict over 35 mosquitoes are potential vectors of Zika virus, suggesting a larger geographic area and a greater human population is at risk of infection.

A key cellular process is controlled by altering a balance, rather than through an off/on mechanism.

The signaling molecule Frizzled3 plays a part in the development of the nervous system by controlling the ability of motor neurons to form connections with distant target muscles.

Dopamine transporter (DAT) interaction with furopyrimidine called AIM-100 in intact cells leads to dramatic oligomerization, nanoclustering and endocytosis of DAT by a novel mechanism coupled to the transporter molecule conformation.