45 results found
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structural inhibition of dynamin-mediated membrane fission by endophilin

    Annika Hohendahl et al.
    The BAR protein endophilin spaces out turns of the dynamin helix, blocking its active conformational change and membrane fission.
    1. Cell Biology
    2. Neuroscience

    Synaptojanin cooperates in vivo with endophilin through an unexpected mechanism

    Yongming Dong et al.
    The Sac1 phosphatase domain, rather than the proline-rich domain, plays an essential role in synaptojanin activity during endocytosis.
    1. Cell Biology
    2. Neuroscience

    Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa

    Fushun Fan et al.
    Analyses of knockout mice and a biochemical screen of interacting proteins reveal that exophilin-8 forms a large network of protein interactions to efficiently retain secretory granules beneath the plasma membrane for exocytosis.
    1. Cancer Biology
    2. Cell Biology

    Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

    Stephin J Vervoort et al.
    Global transcriptome analysis reveals that the transcription factor SOX4 can promote breast tumor development via tumor angiogenesis by promoting paracrine signalling through endothelin-1.
    1. Developmental Biology
    2. Neuroscience

    Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin

    Denise M Poltavski et al.
    Second-order guidance, a novel mechanism by which an initial guidance cue controls expression of a second guidance receptor, is required for precise refinement of axon trajectories during PNS development.
    1. Neuroscience

    Neuroscience: The tortoise and the hare revisited

    Natalia L Kononenko et al.
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    1. Computational and Systems Biology
    2. Ecology

    Data-driven identification of potential Zika virus vectors

    Michelle V Evans et al.
    Data-driven methods predict over 35 mosquitoes are potential vectors of Zika virus, suggesting a larger geographic area and a greater human population is at risk of infection.
    1. Cell Biology

    Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

    Wei-ke Ji et al.
    A key cellular process is controlled by altering a balance, rather than through an off/on mechanism.
    1. Neuroscience

    Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

    Zhong L Hua et al.
    The signaling molecule Frizzled3 plays a part in the development of the nervous system by controlling the ability of motor neurons to form connections with distant target muscles.
    1. Cell Biology
    2. Neuroscience

    Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

    Tatiana Sorkina et al.
    Dopamine transporter (DAT) interaction with furopyrimidine called AIM-100 in intact cells leads to dramatic oligomerization, nanoclustering and endocytosis of DAT by a novel mechanism coupled to the transporter molecule conformation.

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