700 results found
    1. Cell Biology
    2. Neuroscience

    Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins

    Belgin Yalçın et al.
    Proteins of the reticulon and REEP families, homologous to the products of human Hereditary Spastic Paraplegia disease genes, contribute to shaping and continuity of the axonal endoplasmic reticulum network in Drosophila.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1

    Eelco van Anken et al.
    Selective docking of HAC1 mRNA on Ire1 clusters at a site separate from the Ire1 RNase domain is key for endoplasmic reticulum stress signaling.
    1. Cell Biology
    2. Immunology and Inflammation

    Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

    Emma J Fenech et al.
    Interaction mapping of ubiquitin ligase complexes embedded in the endoplasmic reticulum membrane has identified interactors of RNF26 that influence innate immune signalling.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    AMPylation matches BiP activity to client protein load in the endoplasmic reticulum

    Steffen Preissler et al.
    Attaching a molecule of adenosine mono-phosphate (AMP) to the BiP protein at threonine 518 regulates its chaperone activity in the endoplasmic reticulum.
    1. Cell Biology

    Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe

    Nicholas R Guydosh et al.
    A critical component of the cellular response to unfolded proteins is the widespread rescue of ribosomes that stall on endonucleolytically-cleaved mRNA transcripts.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

    Rodney Elwood Infante, Arun Radhakrishnan
    A post-lysosomal cholesterol transport inhibitor reveals how the endoplasmic reticulum membrane regulates total cellular cholesterol by constantly monitoring a critical pool of cholesterol in the plasma membrane.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress

    Jie Wang et al.
    Direct modification by endogenous peroxide of a conserved cysteine in the molecular chaperone BiP decouples its ATPase and peptide-binding activities, allowing for enhanced polypeptide holdase activity during oxidative stress.
    1. Cell Biology

    The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1

    Diego Acosta-Alvear et al.
    The coordination of protein targeting to the endoplasmic reticulum and the unfolded protein response through the stress sensor IRE1 ensures quality control of the secreted and transmembrane proteomes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae

    Xinbo Wang et al.
    Immunoisolation combined with quantitative proteomics identifies 79 proteins enriched in the tubular endoplasmic reticulum and provides useful tool for analyzing this organelle's functions.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

    Steffen Preissler et al.
    Regulation of the endoplasmic reticulum chaperone BiP by calcium.

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