623 results found
    1. Cell Biology
    2. Evolutionary Biology

    The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

    Nicole L Nuckolls et al.
    The Wtf4 antidote protein assembles with the Wtf4 poison protein and promotes the transportation of the assembled proteins to the vacuole for sequestration or destruction.
    1. Developmental Biology

    Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

    Yuto Yoshinari et al.
    Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast

    Sara N Mouton et al.
    In mitotically aging yeast cells, the cytosol acidifies, the distances between the organellar membranes decrease dramatically, but crowding on the scale of the average size protein is relatively stable.
    1. Cell Biology
    2. Computational and Systems Biology

    The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

    Jennifer EL Diaz et al.
    The transcriptomic profiles of the constituent monotherapies of synergistic drug pairs tend to be correlated and result in novel gene expression in the combinations.
    1. Structural Biology and Molecular Biophysics

    Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

    Trayambak Pathak et al.
    Colorectal tumors down-regulate the mitochondrial Na+/Ca2+/Li+ exchanger (NCLX) to alter mitochondrial Ca2+ signaling and initiate transcriptional and metabolic reprogramming that drives tumor chemo-resistance and metastasis.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

    Laura Crowley et al.
    Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.
    1. Cell Biology
    2. Plant Biology

    A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

    Madlen Stephani et al.
    C53 bridges selective autophagy with ribosome-associated quality control at the endoplasmic reticulum.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An ER translocon for multi-pass membrane protein biogenesis

    Philip T McGilvray et al.
    A set of ER-localized membrane proteins whose loss causes developmental diseases in humans, assemble with Sec61 into a translocon that facilitates the biogenesis of hundreds of different multi-pass membrane proteins.
    1. Cancer Biology
    2. Cell Biology

    Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

    Yingqi Liu et al.
    PRMT7-mediated SHANK2 methylation regulates breast cancer metastasis by activating endosomal FAK signals, and may provide potential clues for tumour metastasis treatment strategies.

Refine your results by:

Type
Research categories