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    1. Cell Biology

    Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

    Satoshi Tsunoda et al.
    Adapting a cytosolic enzyme that breaks down glutathione to function in the lumen of the endoplasmic reticulum challenges the long-held view that reduced glutathione fuels disulfide rearrangements during protein folding.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress

    Mable Lam et al.
    Death receptor 5 can directly sense misfolded proteins downstream of the endoplasmic reticulum to provide a quality control mechanism that executes apoptosis and prevents further production of misfolded proteins.
    1. Cell Biology
    2. Neuroscience

    The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes

    Abigail G Garrity et al.
    The endoplasmic reticulum serves as a direct and primary source of calcium ions for the lysosome.
    1. Cell Biology

    TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export

    António JM Santos et al.
    Building on previous work (Nogueira et al., 2014), we describe a mechanism for the generation of a mega-carrier for the export of bulky procollagen from the endoplasmic reticulum.
    1. Cell Biology

    Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network

    Songyu Wang et al.
    Experiments with mammalian cells and Xenopus egg extracts elucidate how three proteins cooperate to shape the reticular endoplasmic reticulum network.
    1. Cell Biology

    The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

    Rolf M Schmidt et al.
    Endoplasmic reticulum stress in yeast activates not only the UPR but also Rpn4, promoting the clearance of misfolded proteins from the cytosol as part of a modular cross-compartment stress response.
    1. Cell Biology

    Unfolded protein response transducer IRE1-mediated signaling independent of XBP1 mRNA splicing is not required for growth and development of medaka fish

    Tokiro Ishikawa et al.
    The unfolded protein response sensor/transducer IRE1-mediated splicing of XBP1 mRNA encoding its active downstream transcription factor to maintain the homeostasis of the endoplasmic reticulum is sufficient for growth and development of medaka fish.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The architecture of EMC reveals a path for membrane protein insertion

    John P O'Donnell et al.
    Structural and biochemical analysis of an abundant and conserved protein complex called EMC shows how it is likely to insert nascent membrane proteins into the endoplasmic reticulum membrane.
    1. Structural Biology and Molecular Biophysics

    ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein

    Horia Vais et al.
    Calcium release from the endoplasmic reticulum through the IP3 receptor ion channel is strongly regulated by a calcium-binding protein in the lumen of the endoplasmic reticulum.