21 results found
    1. Developmental Biology

    Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut

    Erez Cohen et al.
    Ploidy-increasing endocycles may represent a tradeoff between loss of regenerative capacity and preservation of tissue architecture.
    1. Plant Biology

    Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal

    Heather M Meyer et al.
    Fluctuations of a transcription factor that coincide with the G2 phase of the cell cycle pattern two interspersed cell fates in a multicellular system.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance

    Scott Berry et al.
    Two copies of a Polycomb target gene in the same cell can be maintained in independently heritable expression states, demonstrating that long-term memory of gene expression is stored locally.
    1. Plant Biology

    A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

    Naoki Takahashi et al.
    Arabidopsis deploys the core signalling module that perceives distinct stress signals, such as DNA damage and heat stresses, and represses G2/M-specific genes, thereby causing cell cycle arrest.
    1. Cell Biology

    Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in C. elegans

    Nikolay Burnaevskiy et al.
    Morphological and functional rejuvenation upon exit from adult reproductive diapause in C. elegans is independent of germline signaling, but instead involves somatic nucleolar activation and expansion of the RNA pool.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage

    Timothy J Wendorff, James M Berger
    The engagement of DNA crossings is shown to license ATP hydrolysis and DNA cleavage by topoisomerase VI, a finding with mechanistic ramifications for related GHKL ATPases and meiotic recombination machineries.
    1. Cell Biology
    2. Developmental Biology

    Plasticity of both planar cell polarity and cell identity during the development of Drosophila

    Pedro Saavedra et al.
    In the Drosophila larval epidermis both the cell identity and polarity of individual cells change as a result of cell rearrangements.
    1. Stem Cells and Regenerative Medicine

    Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss

    Judy Lisette Martin et al.
    A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.
    1. Chromosomes and Gene Expression

    The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci

    Anand K Singh et al.
    UPF1 associates with nascent transcripts and plays a broad role in nuclear processes of gene expression.

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