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Using cytosolic explants from Drosophila syncytial embryos combined with quantitative microscopy and perturbations, the mechanical forces separating Drosophila microtubule asters are revealed.

Proteomic and metabolomic analyses reveal how mannose exerts its anticancer activity.

UPF1 associates with nascent transcripts and plays a broad role in nuclear processes of gene expression.

A subset of intestinal precursor cells is able to sense mechanical forces at cell–cell junctions to control the production of specialised cells.

The transcription factor Lola is defined as a non-canonical Hippo signaling component essential for Drosophila midgut homeostasis via its interaction with Warts and suppression on Dref and SkpA expression levels.

The engagement of DNA crossings is shown to license ATP hydrolysis and DNA cleavage by topoisomerase VI, a finding with mechanistic ramifications for related GHKL ATPases and meiotic recombination machineries.

The machinery that carries out programmed DNA rearrangements is composed of domesticated transposases. One is catalytically active, five play architectural function essential for the accuracy of the process.

A giant multifunctional protein complex mediates mating-type recognition through a non-ligand–receptor mechanism in a multisexual species.

Radial plant growth produces large parts of terrestrial biomass and can be computationally simulated with the help of an instructive framework of intercellular communication loops.