Arabidopsis deploys the core signalling module that perceives distinct stress signals, such as DNA damage and heat stresses, and represses G2/M-specific genes, thereby causing cell cycle arrest.
Genetic analyses illustrate the novel requirement of Ftz-f1 and Sim in adult Drosophila ovaries for regulating follicle cell differentiation and ovulation that is likely conserved in mammals.
Human cell lines replicate and proliferate without ORC1 or ORC2, two subunits of the replication initiator protein complex ORC, which has till now been considered essential for DNA replication.
Naama Flint Brodsly, Eliya Bitman-Lotan ... Amir Orian
Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
Nuclei of the true slime mold Physarum polycephalum are continuously shuttled within the cytoplasmic flow across the gigantic syncytium, yet Physarum can establish and maintain gene expression heterogeneity between different structures of the organism.
Two copies of a Polycomb target gene in the same cell can be maintained in independently heritable expression states, demonstrating that long-term memory of gene expression is stored locally.
Hsiang-Chen Chou, Kuhulika Bhalla ... Bruce Stillman
The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
