692 results found
    1. Stem Cells and Regenerative Medicine

    Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury

    Terren K Niethamer et al.
    Single-cell RNA sequencing reveals extensive endothelial cell (EC) heterogeneity throughout the lung vasculature and identifies two distinct populations, Car4-high ECs and proliferative ECs, that preferentially respond to lung injury.
    1. Chromosomes and Gene Expression

    Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells

    Nicholas T Hogan et al.
    An integrative genome-wide approach supports a direct and collaborative role of ETS and AP-1 transcription factors in maintaining endothelial cell-specific and anti-inflammatory gene expression programs.
    1. Genetics and Genomics
    2. Neuroscience

    A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture

    Mark F Sabbagh, Jeremy Nathans
    In vitro culture of brain endothelial cells leads to a rapid loss of the blood-brain barrier transcriptional and accessible chromatin landscapes that is resistant to the effects of beta-catenin stabilization.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cardiac endothelial cells maintain open chromatin and expression of cardiomyocyte myofibrillar genes

    Nora Yucel et al.
    Endothelial cells in the heart have transcriptional and epigenetic signatures of cardiomyocytes.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

    Mark F Sabbagh et al.
    Genome-wide integration of transcriptome, accessible chromatin, and DNA methylome data from vascular endothelial cells lays the foundation for understanding the gene regulatory circuits that generate organ-specific vascular specialization.
    1. Chromosomes and Gene Expression
    2. Medicine

    Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells

    Karthik Amudhala Hemanthakumar et al.
    Endothelial dysfunction due to cardiovascular disease risk factors explained by cardiac endothelial cell transcriptome remodelling.
    1. Cell Biology
    2. Developmental Biology

    EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity

    Maike Frye et al.
    EphrinB2/EphB4-mediated regulation of cytoskeletal contractility is a key homeostatic mechanism of lymphatic endothelial cell-cell junction maintenance, and provides a potential target for therapeutic modulation of lymphatic vessel permeability and function.
    1. Cell Biology
    2. Genetics and Genomics

    Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution

    Fabrizio Orsenigo et al.
    Single-cell RNA analysis of brain endothelium identifies the angiogenic venous capillary subset and respective resident endothelial progenitors at the origin of CCM lesions, while arterial endothelial cells are unaffected.
    1. Cell Biology
    2. Computational and Systems Biology

    A regulatory microRNA network controls endothelial cell phenotypic switch during sprouting angiogenesis

    Stefania Rosano et al.
    Coordinated microRNAs activity induced by VEGF represses cell proliferation and favors cell migration at the onset of sprouting angiogenesis in endothelial cells.
    1. Cell Biology
    2. Developmental Biology

    Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity

    Bart-Jan de Kreuk et al.
    The proteins Heart of Glass (HEG1) and Rasip1 are both essential for cardiovascular development; and directly bind to each other to guide Rasip1 to endothelial cell junctions to support vascular integrity.

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