1,387 results found
    1. Medicine

    Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets

    Mateusz Maciejewski, Eugen Lounkine ... Laszlo Urban
    Careful analysis of adverse drug reaction reports reveals noise and biases embedded in this data and allows for systematic mitigation of these effects to produce much more robust understanding of side effects of marketed drugs.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    SARS-CoV-2 shedding dynamics across the respiratory tract, sex, and disease severity for adult and pediatric COVID-19

    Paul Z Chen, Niklas Bobrovitz ... Frank X Gu
    COVID-19 severity, rather than sex or age, predicts SARS-CoV-2 kinetics, and SARS-CoV-2 viral load from lower respiratory tract specimens may predict severe disease days before clinical deterioration for COVID-19 patients.
    1. Ecology
    2. Evolutionary Biology

    Heart fossilization is possible and informs the evolution of cardiac outflow tract in vertebrates

    Lara Maldanis, Murilo Carvalho ... José Xavier-Neto
    The discovery of a fossil heart in Rhacolepis buccalis demonstrates that it is possible to scrutinize the fossil record for important clues on cardiac structure and evolution.
    1. Epidemiology and Global Health
    2. Medicine

    Cardiovascular disease and subsequent risk of psychiatric disorders: a nationwide sibling-controlled study

    Qing Shen, Huan Song ... Unnur Valdimarsdóttir
    Patients diagnosed with a cardiovascular disease are at higher risk of psychiatric disorders, independent of familial factors shared between full siblings and comorbid conditions.
    1. Neuroscience

    Task-related hemodynamic responses in human early visual cortex are modulated by task difficulty and behavioral performance

    Charlie S Burlingham, Minyoung Ryoo ... Elisha P Merriam
    The fMRI-BOLD signal in human early visual cortex reflects alertness and behavioral performance on the timescale of individual trials.
    1. Neuroscience

    Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology

    Xiling Bian, Jiemin Zhu ... Yi Rao
    While neurotransmitters were discovered decades ago, evidence suggests that more transmitters are to be discovered using the presented approaches.
    1. Microbiology and Infectious Disease

    The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus

    Belinda Baquero-Perez, Agne Antanaviciute ... Adrian Whitehouse
    SND1 has m6A-reading ability and is essential for Kaposi's sarcoma-associated lytic replication.
    1. Biochemistry and Chemical Biology

    Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice

    Yuna Izumi-Mishima, Rie Tsutsumi ... Hiroshi Sakaue
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation
    2. Neuroscience

    A microglia clonal inflammatory disorder in Alzheimer’s Disease

    Rocio Vicario, Stamatina Fragkogianni ... Frederic Geissmann
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Physics of Living Systems

    Vein fate determined by flow-based but time-delayed integration of network architecture

    Sophie Marbach, Noah Ziethen ... Karen Alim
    Relative hydraulic resistance, shear rate, and pressure in a vascular network integrate the network's architecture via fluid flow, and determine vein dynamics, with a time delay, in the prototypical organism Physarum polycephalum.

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