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    1. Biochemistry and Chemical Biology

    Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice

    Yuna Izumi-Mishima, Rie Tsutsumi ... Hiroshi Sakaue
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Evolutionary Biology

    Evolution of an extreme hemoglobin phenotype contributed to the sub-Arctic specialization of extinct Steller’s sea cows

    Anthony V Signore, Phillip R Morrison ... Kevin L Campbell
    Resurrected Steller’s sea cow hemoglobin exhibits novel functional traits underlying their adaptation to the sub-Arctic.
    1. Ecology

    Meta-analysis reveals glucocorticoid levels reflect variation in metabolic rate, not ‘stress’

    Blanca Jimeno, Simon Verhulst
    Glucocorticoids are assumed to reflect 'stress,' but they increase proportionally to the increase in metabolic rate induced by stressors, leading us to propose that glucocorticoids reflect metabolic rate, not stress.
    1. Structural Biology and Molecular Biophysics

    High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter

    Shamayeeta Ray, Samuel P Berry ... Rachelle Gaudet
    Structures of a transition metal transporter spanning the entire Mn2+ transport cycle reveal distinct coordination geometries and dynamic polar networks that enable Mn2+ import, and a Cd2+-bound structure helps explain how Cd2+ behaves differently as a substrate.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin

    Haiyang Liu, Jianchao Li ... Mingjie Zhang
    The tail domain of Myosin III binds to and cross-links actin bundling protein Espin1 and thus modulates higher order actin bundle structures in cellular processes such as stereocilia and microvilli.
    1. Developmental Biology
    2. Evolutionary Biology

    Coronary artery established through amniote evolution

    Kaoru Mizukami, Hiroki Higashiyama ... Hiroki Kurihara
    During the evolution of amniotes, the transformation of branchial arches coincided with the drastic remodeling of the ancestral extrinsic cardiac arteries, giving rise to novel ventricular coronary arteries that are unique to amniotes.
    1. Ecology

    Countercurrent heat exchange and thermoregulation during blood-feeding in kissing bugs

    Chloé Lahondère, Teresita C Insausti ... Claudio R Lazzari
    A novel thermoregulatory mechanism in blood-sucking insects, vectors of human disease, is described using a functional-morphological approach.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

    Hannah K Long, David Sims ... Robert J Klose
    Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.
    1. Neuroscience

    Thermoregulation: How a brain keeps its cool

    Swathi Yadlapalli, Orie T Shafer
    Temperature-sensing neurons in the Drosophila brain cooperate with the central circadian clock to help regulate body temperature.
    Version of Record
    Insight
  1. Annual report: Looking back on 2017

    A reflection on eLife's achievements in 2017, notably in convening and supporting communities, modernising technology for research communication and partnering with early-career researchers.