380 results found
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Characterizing human mobility patterns in rural settings of sub-Saharan Africa

    Hannah R Meredith et al.
    Mobile phone data reveal aspects of human mobility patterns in Sub-Saharan Africa missed by standard spatial models however, model estimates can be improved by accounting for trip urbanicity and region.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    The structure of photosystem I from a high-light-tolerant cyanobacteria

    Zachary Dobson et al.
    The necessity of studying extremophile organisms is exemplified by the structure of photosystem I from a high-light tolerant cyanobacteria, demonstrating the relationship between the structure and function in photosystem I.
    1. Genetics and Genomics

    Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity

    Stephen M Blazie et al.
    The eIF3 translation initiation complex exerts specific regulation on neuronal protein levels by targeting mRNAs with GC-rich 5' UTR.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural intermediates observed only in intact Escherichia coli indicate a mechanism for TonB-dependent transport

    Thushani D Nilaweera et al.
    Pulse electron paramagnetic resonance on intact Escherichia coli reveals a substrate-induced structural transition in BtuB, the vitamin B12 transporter, which is not seen in reconstituted membranes and indicates a mechanism of transport.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Development of antibacterial compounds that constrain evolutionary pathways to resistance

    Yanmin Zhang et al.
    Integrated multi-scale, multi-tool approach to design novel 'evolution drugs' which can delay the emergence of antibiotic resistance by constraining bacterial evolutionary escape strategies.
    1. Physics of Living Systems

    Effect of malaria parasite shape on its alignment at erythrocyte membrane

    Anil K Dasanna et al.
    A numerical model of malaria parasite adhesion to an erythrocyte shows that the original egg-like shape of merozoites is more robust than other shapes in negotiating various physiological conditions during the alignment process upon erythrocyte invasion.
    1. Cell Biology
    2. Developmental Biology

    Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules

    Patricia Giselle Cipriani et al.
    Two novel LOTUS-domain proteins are core germ granule components that directly recruit Caenorhabditis elegans Vasa, regulate germ granule size and localization, and provide an organizational framework for ribonucleoprotein complexes.
    1. Ecology

    An octopamine receptor confers selective toxicity of amitraz on honeybees and Varroa mites

    Lei Guo et al.
    The structural and pharmacological difference of the invertebrate counterpart of β-adrenergic receptor confers selective toxicity of an insecticide on honeybees and their devastating parasite Varroa mites.
    1. Neuroscience
    2. Physics of Living Systems

    The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

    Zhenyong Wu et al.
    During neurotransmitter release, calcium-induced membrane insertion of the C2B domain of Synaptotagmin re-orients the bound SNARE complex which dilates the fusion pore in a mechanical lever action.
    1. Physics of Living Systems

    Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila

    Myron Barber Child VI et al.
    Biophysical modeling and quantitative live-cell imaging converge to show that the century-old puzzle of somatic homolog pairing in Drosophila operates via a button model.

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