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The Acyl-CoA binding domain-containing 7 (Acbd7) gene is expressed in the hypothalamus, encodes a peptide that suppresses appetite, increases metabolic rate and interacts with the leptin-melanocortin system.

Two distinct processes drive coordinated synthesis of purine and pyridine (NAD⁺) nucleotides in response to AICAR derivatives and ATP.

Mitochondrial flashes have a central role in ensuring that ATP levels remain constant in heart cells.

Animal models reveal that mitochondrial complex I is dispensable for homeostatic functions of the mouse liver.

Hungry flies shifting from cooler to warmer temperature preferences in response to non-nutritive food indicates a taste-triggered response, similar to the cephalic phase response observed in mammals.

Autophagy and Lkb1 work synergistically to maintain adult mouse homeostasis and survival.

Iron content in neural stem cells controlled by glial ferritin is critical for self-renewal and proliferation of neural stem cells.

The health benefits of caloric restriction, including decreasing body fat and blood glucose, differ between males and females and this difference depends on the age at which caloric restriction begins.

A combination of neuroscience approaches and indirect calorimetry demonstrate a physiological role for AgRP neurons in cold-induced hyperphagia and strongly suggest temperature is an important regulator of AgRP neuron activity.

Brain imaging and behavioral analysis reveal two opposing states of hunger, represented by anti-correlated lateral and caudal hypothalamic dynamics that are important for the homeostatic control of feeding in zebrafish.