712 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mapping transiently formed and sparsely populated conformations on a complex energy landscape

    Yong Wang et al.
    Molecular simulations can capture key aspects of the conformational exchange in a protein.
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways

    Sukrit Suksombat et al.
    Single-molecule force and fluorescence spectroscopy reveal the structural states and dynamics of E. coli single-stranded DNA binding proteins and the energy landscape of the nucleo–protein complex.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins

    Sylvain Zorman et al.
    The energy landscape of SNARE folding and assembly is optimized for efficient stage-wise membrane fusion.
    1. Structural Biology and Molecular Biophysics

    Changes in the free-energy landscape of p38α MAP kinase through its canonical activation and binding events as studied by enhanced molecular dynamics simulations

    Antonija Kuzmanic et al.
    Extensive molecular dynamics simulations enhanced by advanced sampling techniques give a detailed view of p38α canonical activation mechanism, which reveals novel key electrostatic interactions that are put in context of existing experimental data.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational distributions of isolated myosin motor domains encode their mechanochemical properties

    Justin R Porter et al.
    Shifts in the balance between nucleotide-favorable and nucleotide-unfavorable conformations of myosin motors encode duty ratios and ADP release rates, demonstrating the power of an ensemble perspective for uncovering sequence-function relationships.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase

    Wen Ma et al.
    Integration of structural bioinformatics and free-energy simulations reveals how a helicase switches its function from unwinding to rezipping DNA, during which a key metastable conformation is predicted and verified by single-molecule measurements.
    1. Physics of Living Systems

    Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis

    Lu Ma et al.
    The Munc18-1 protein promotes formation of the t-SNARE complex and the half-zippered SNARE complex, two rate-limiting steps of SNARE assembly, to enhance membrane fusion.
    1. Structural Biology and Molecular Biophysics

    Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

    Ashok Sekhar et al.
    Solution NMR spectroscopy reveals the energy landscape of immature Cu, Zn-superoxide dismutase and leads to atomic resolution structural models of transiently populated non-native oligomers.
    1. Structural Biology and Molecular Biophysics

    Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography

    Daniel A Keedy et al.
    The conformations of the enzyme cyclophilin A that are essential for its catalytic activity are temperature dependent and exhibit diverse responses, which is consistent with a complex energy landscape.
    1. Computational and Systems Biology

    Science Forum: Wikidata as a knowledge graph for the life sciences

    Andra Waagmeester et al.
    Wikidata is continuously-updated resource that could improve the efficiency and accuracy of research in many areas of the life and biomedical sciences.

Refine your results by:

Type
Research categories