2,737 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress

    Jinyang Wang, Yaxin Wen ... Qinxi Li
    Acetate concentration, which is significantly increased in association with energy stresses such as those that occur with diabetes or starvation, is emerging as a novel 'ketone body' with potential as a parameter for evaluating the progression of energy stress.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

    Ana Tamarkin-Ben-Harush, Jean-Jacques Vasseur ... Rivka Dikstein
    Differential eIF4E binding to transcription initiation nucleotides and alternative promoter usage of eIF1A, PABP and other genes are involved in the response of the translation machinery to energy stress.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Toxoplasma bradyzoites exhibit physiological plasticity of calcium and energy stores controlling motility and egress

    Yong Fu, Kevin M Brown ... L David Sibley
    Live-cell imaging and biochemical studies reveal that bradyzoites exhibit reduced Ca2+ stores, dampened calcium responses, and reduced energy levels consistent with their quiescent sate, but that they rapidly respond to environmental conditions to emerge from dormancy.
    1. Ecology
    2. Evolutionary Biology

    Reversal of the adipostat control of torpor during migration in hummingbirds

    Erich R Eberts, Christopher G Guglielmo, Kenneth C Welch Jr
    Ruby-throated hummingbirds switch from using torpor to survive nighttime energy emergencies in the breeding season to using it to spare fat stores and gain premigratory mass in the late summer.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    New insights into the cellular temporal response to proteostatic stress

    Justin Rendleman, Zhe Cheng ... Christine Vogel
    A time-resolved analysis of protein and RNA concentrations and interactions during proteostasis stress highlights the dominant role of translation regulation and a shift of energy metabolism.
    1. Biochemistry and Chemical Biology

    daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival

    Jonathan D Hibshman, Alexander E Doan ... L Ryan Baugh
    daf-16/FoxO restructures metabolism during acute starvation to promote synthesis of trehalose, which supports survival as a stress protectant and energy source.
    1. Plant Biology

    ATP sensing in living plant cells reveals tissue gradients and stress dynamics of energy physiology

    Valentina De Col, Philippe Fuchs ... Markus Schwarzländer
    The monitoring of ATP dynamics in living plants using fluorescent protein biosensor provides evidence for the complex relationship between cellular energy status and growth.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

    Ariel Ogran, Tal Havkin-Solomon ... Rivka Dikstein
    Examination of the changes in the transcription start site selection in TCL1-driven chronic lymphocytic leukemia and their impact on mRNA translation revealed a marked elevation of intra-genic cryptic promoters, which are predicted to generate multiple N-terminally truncated or modified proteins.
    1. Structural Biology and Molecular Biophysics

    Three dimensional reconstruction of energy stores for jumping in planthoppers and froghoppers from confocal laser scanning microscopy

    Igor Siwanowicz, Malcolm Burrows
    Three dimensional reconstructions of the mechanical energy stores of jumping insects reveal how the miniaturized components interact and function.
    1. Biochemistry and Chemical Biology
    2. Ecology

    The energy savings-oxidative cost trade-off for migratory birds during endurance flight

    Scott McWilliams, Barbara Pierce ... Ulf Bauchinger
    Migratory birds with fuel stores composed of more omega-6 fats saved energy during long-duration flights, but this short-term energy saving came at the long-term cost of higher oxidative damage.

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