Two distinct genetic biocontrol methods work synergistically to yield a novel approach in the fight against pest organisms.

Loss of YAP1/TAZ expression in the pancreatic endocrine compartment is not a passive consequence of endocrine specification, rather, Hippo pathway-mediated inhibition of YAP1/TAZ in endocrine progenitors is a prerequisite for endocrine specification and differentiation.

The hormonal circuitry controlling development in plants can be studied and re-programmed with hormone activated Cas9-based repressors.

Selective activation of FZD7 signaling with an engineered WNT mimetic promotes early developmental programs, including endodermal lineage specification, in human pluripotent stem cells.

An empirically derived scoring system for identifying optimal communication modules of aptazymes accelerates the development of ligand-responsive RNA genetic switches functional in mammalian cells.

Transcriptional signature and cell morphology of the stroke-associated microglia are reprogrammed by distinct T cell subpopulations.

A transcriptome-based pipeline (scAAVengr) quantifies and ranks competing adeno-associated viral vectors in primate retina, and mouse brain, heart, and liver, simultaneously and across all cell types, in the same animal, with single-cell resolution.

Altering the level of different oncogenic mutants of Kras induces unique tumor patterns in mice, suggesting that tissue-specific responses mold the sensitivity of normal tissues to different oncogenic RAS mutations.

Light-sensitive allosteric switch module, a broadly applicable protein engineering method, is used for the regulation of protein activity with tight temporal control and spatial precision.

Engineered mesenchymal stem cells (MSCs) could produce mutant β-galactosidase and trigger nitric oxide (NO) release when the NO prodrug is systemically administered, which can achieve NO release in a precise spatiotemporal manner and augment the therapeutic efficiency of MSCs.