The entire biosynthetic pathway for the diterpenoid forskolin in Coleus forskohlii has been reconstituted in yeast.

The hormonal circuitry controlling development in plants can be studied and re-programmed with hormone activated Cas9-based repressors.

Selective activation of FZD7 signaling with an engineered WNT mimetic promotes early developmental programs, including endodermal lineage specification, in human pluripotent stem cells.

Using barcoded mutagenesis and a high-throughput genetic screen results in the identification of 150 genes that affect lipid accumulation in a non-model yeast system.

A chemogenetic tool has been developed to map and manipulate neuronal circuits with spatial and temporal precision.

A new animal model permits the in vivo study of HIV-1 entry, as well as the elicitation and antiviral activity of antibodies, in a genetically manipulatable host.

Light-sensitive allosteric switch module, a broadly applicable protein engineering method, is used for the regulation of protein activity with tight temporal control and spatial precision.

Hedgehog acts as a morphogen by regulating proteolytic processing and activation of full-length Ci/Gli transcriptional effectors but can pattern Drosophila wing discs normally in the absence of regulated proteolytic processing.

Minimal genetic modifications of endogenous mosquito genes allow the tissue-specific expression of anti-malarial effectors and convert them into efficient non-autonomous gene drives.

Diverse K_ATP channel inhibitors occupy a common binding pocket and stabilize an interaction between Kir6.2 and SUR1 to allosterically control gating and promote the assembly and trafficking of nascent channels.