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Biochemistry and Chemical Biology
Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells
Guocai Zhong et al.
An empirically derived scoring system for identifying optimal communication modules of aptazymes accelerates the development of ligand-responsive RNA genetic switches functional in mammalian cells.
Chromosomes and Gene Expression
Deletion of the
spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma
Floris Foijer et al.
Chromosomal instability through spindle assembly checkpoint alleviation facilitates malignant transformation of hepatocytes and T-cells in vivo, resulting in cancers with recurrent karyotypes.
Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes
Wen Xu et al.
Gene sharing through different isoforms can precede the formation of independent genes.
Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening
Carla S Verissimo et al.
Libraries of patient-derived tumor organoids are a reliable and scalable model system that can help identify and optimize targeted therapies in a pre-clinical setting.
Immunology and Inflammation
Microbiology and Infectious Disease
Reprogramming the antigen specificity of B cells using genome-editing technologies
James E Voss et al.
Antibody paratopes can be added to the human repertoire by CRISPR-Cas9 editing of B lymphocytes using a strategy that allows for hypermutation and class switching of resulting B cell receptors.
Structural Biology and Molecular Biophysics
The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies
Matthew A Cottee et al.
The structure of the Ana2 Central Coiled-Coil Domain provides insight into how centriolar cartwheel components may be recruited and assembled, and indicates that cartwheel assembly involves more than just SAS-6 oligomerisation.
Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish
Brent W Bisgrove et al.
Maternal Gdf3 and Nodal are interdependent obligatory cofactors in the fundamental patterning of the vertebrate embryonic axis of zebrafish.
Physics of Living Systems
Mechanical design principles of a mitotic spindle
Jonathan J Ward et al.
Precise control of microtubule architecture greatly increases the force that the spindle can exert on chromosomes.
Abscisic acid dynamics in roots detected with genetically encoded FRET sensors
Alexander M Jones et al.
Fluorescent sensors for the hormone abscisic acid have been developed using a high-throughput platform, and used to monitor hormone dynamics in plant roots and leaves.
Biochemistry and Chemical Biology
Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin
Melissa V Gammons et al.
An unusual molecular mechanism has been revealed based on ultrastable histidine cluster co-aggregation underlying feedback control of an ancient cell communication pathway.
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