A mammalian protein with RNA recognition motifs can be used in bacteria to engineer post-transcriptional regulation.

The structure of the VemP-stalled ribosome reveals a helix-double turn-helix conformation of the nascent chain within the ribosomal tunnel, illustrating how secondary structure formation directly at the peptidyltransferase center of the ribosome can induce translational arrest.

Measurements of transcript isoform specific translation across the human genome reveal that isoforms from the same gene can differ in protein production by two orders of magnitude.

Engineered E3 ubiquitin ligases are utilized to elucidate mechanisms underlying ubiquitin regulation of membrane proteins, and to achieve robust post-translational functional knockdown of ion channels.

Asc1/RACK1 promotes the translation of mRNAs associated with the translational closed loop complex, which have short open reading frames and encode proteins required for core metabolic processes.

Engineered mesenchymal stem cells (MSCs) could produce mutant β-galactosidase and trigger nitric oxide (NO) release when the NO prodrug is systemically administered, which can achieve NO release in a precise spatiotemporal manner and augment the therapeutic efficiency of MSCs.

Cells resolve unassigned codons with near-cognate suppression, frameshifting, and ribosomal rescue mechanisms, demonstrating that unassigned codons are permissible in both natural and engineered genetic codes as barriers to horizontal gene transfer.

A new mechanism of Rvb1/Rvb2 proteins was found that couples transcription, mRNA granular localization and translation of select genes during glucose starvation stress.

A method that involves simultaneous tracking of individual mRNAs and their associated ribosomes can be used to determine when and where individual molecules get translated in living cells.

Secondary metabolites rocaglates produced by plants lead to a plant‒fungus tug-of-war, utilizing unique amino acid substitutions in eIF4A, a target of the compounds.