2,067 results found
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    3D imaging of Sox2 enhancer clusters in embryonic stem cells

    Zhe Liu et al.
    Lattice light-sheet single-molecule imaging shows 3D Sox2 enhancer clusters in live embryonic stem cells and reveals a model linking 3D spatial distribution of cis-elements, differential target search features and localized gene regulation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency

    Maxim Greenberg et al.
    Three-dimensional chromatin architecture facilitates a promoter switch in order to ensure maintained expression of a gene involved in growth during embryonic stem cell differentiation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Controlling gene activation by enhancers through a drug-inducible topological insulator

    Taro Tsujimura et al.
    A novel synthetic DNA cassette of CTCF-binding sites combined with the drug-controllable induction system of heterochromatin enabled switchable blocking of chromatin conformation and gene-enhancer interaction.
    1. Chromosomes and Gene Expression

    Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity

    Jeffrey M Alexander et al.
    Sox2 transcription is not correlated with spatial proximity of its essential regulatory enhancer in embryonic stem cells, suggesting gene transcription is not limited to periods of direct enhancer-promoter contact.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Influenza A virus surface proteins are organized to help penetrate host mucus

    Michael D Vahey, Daniel A Fletcher
    By distributing receptor-binding and receptor-destroying proteins asymmetrically on their surface, filamentous influenza A virus particles create a Brownian ratchet that facilitates their passage through mucus.
    1. Cell Biology
    2. Ecology

    Systems analysis of the CO2 concentrating mechanism in cyanobacteria

    Niall M Mangan, Michael P Brenner
    Systems level modeling of cyanobacterial mechanism for concentrating carbon dioxide shows optimal organization and enzymatic activity for enhanced carbon fixation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

    Elias T Friman et al.
    OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.
    1. Developmental Biology

    Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling

    Xin Huang et al.
    Post-implantation epiblast maturation and patterning of anterior-posterior axis in mouse embryonic development are mediated by pluripotency transcription factor Zfp281 through transcriptional and epigenetic control of Nodal signaling.
    1. Cell Biology
    2. Physics of Living Systems

    Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice

    Kaushikaram Subramanian et al.
    Establishing retinal contrast transmission as a novel determinant of mammalian fitness, this research adds functional significance to a prominent exception of nuclear organization, previously described in nocturnal rod photoreceptor cells.
    1. Cell Biology

    CHIP as a membrane-shuttling proteostasis sensor

    Yannick Kopp et al.
    The mechanism is revealed that connects the protein degradation machinery to cellular membrane-bound compartments during proteostasis stress in mammalian cells.

Refine your results by:

Type
Research categories