3,983 results found
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Multi-enhancer transcriptional hubs confer phenotypic robustness

    Albert Tsai et al.
    Multiple enhancers in physical proximity can reinforce shared transcriptional 'hubs' to preserve their transcriptional output, providing a buffer during environmental stresses and genetic perturbations to preserve phenotypic robustness.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    N-chlorination mediates protective and immunomodulatory effects of oxidized human plasma proteins

    Agnes Ulfig et al.
    N-chlorination, a reversible, oxidative modification, turns plasma proteins into holdase-like chaperones, potent activators of immune cells and pro-survival factors for phagocytic immune cells.
    1. Neuroscience

    Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors

    Jessie R Scheimann et al.
    Development of a conditional glucocorticoid receptor knockdown rat model allows for high resolution anatomical, physiological and behavioral exploration into the role of glucocorticoid receptor signaling in defined cell populations.
    1. Neuroscience

    Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila

    Noa Bielopolski et al.
    Muscarinic acetylcholine receptor type A in adult Drosophila inhibits Kenyon cells, and is required for aversive olfactory learning and learning-associated synaptic depression between Kenyon cells and their output neurons.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq

    Dylan Kotliar et al.
    A novel algorithm, consensus non-negative matrix factorization (cNMF), accurately identifies gene expression programs underlying cell-type identity and cellular activities from single-cell RNA-Seq data.
    1. Neuroscience

    Network-wide abnormalities explain memory variability in hippocampal amnesia

    Georgios PD Argyropoulos et al.
    Hippocampal damage is associated with changes across the extended hippocampal system, and these may explain variability in memory between patients presenting with hippocampal amnesia.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport

    Konstadinos Moissoglu et al.
    RNAs enriched at cell protrusions are translated regardless of their location in the cytoplasm but are dynamically repressed in retracting protrusions and incorporated into heterogeneous RNA clusters.
    1. Neuroscience

    More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction

    Baoqiang Li et al.
    Resting-state capillary blood flow and oxygenation are more homogeneous in the deeper cortical layers, underpinning an important mechanism by which the microvascular network adapts to an increased local oxidative metabolism.

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