4,067 results found
    1. Neuroscience

    Chronically implanted Neuropixels probes enable high-yield recordings in freely moving mice

    Ashley L Juavinett et al.
    A new device enables researchers to use and recycle extracellular electrodes (e.g. Neuropixels) for high-yield recordings during freely moving mouse experiments.
    1. Evolutionary Biology

    Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

    Anett Dunai et al.
    Drug-resistance declines in the laboratory in an antibiotic stress-free environment, indicating that restricting antimicrobial usage in the clinics could be a useful policy.
    1. Neuroscience

    Mapping the human subcortical auditory system using histology, postmortem MRI and in vivo MRI at 7T

    Kevin R Sitek et al.
    MRI methods are promising techniques for investigating the human subcortical auditory system, and these publicly available data, atlases, and tools make researching human audition simpler and more reliable.
    1. Developmental Biology

    Two-step regulation of trachealess ensures tight coupling of cell fate with morphogenesis in the Drosophila trachea

    Takefumi Kondo, Shigeo Hayashi
    The Drosophila tracheal fate is stabilized by the combination of transcriptional programs to control tissue architecture and tissue-level input sensitive to tubular geometry, ensuring the robust mechanism of organ determination.
    1. Structural Biology and Molecular Biophysics

    Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain

    Zhicheng Zuo et al.
    The catalytic activation of the Cas9 HNH domain involves a unique conformational change in the ββα-metal motif that is collectively driven by the interactions with the metal ions and DNA.
    1. Cell Biology

    Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk

    Olga Afonso et al.
    Quantitative live-cell microscopy and molecular perturbations in Drosophila and human cells reveal a crosstalk between molecular 'rulers' (Aurora B) and 'clocks' (Cdk1) that coordinates mitotic exit in space and time.
    1. Cancer Biology

    Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

    Shun Kishimoto et al.
    Using noise suppression, real-time imaging of glucose metabolism is possible by 13C MRI and reveals previously undetected metabolic differences within tumors.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A single K+-binding site in the crystal structure of the gastric proton pump

    Kenta Yamamoto et al.
    Crystal structures provide structural rationales for the transport stoichiometry of the gastric proton pump, which suffices the energy requirement for the generation of a million-fold proton gradient across the membrane.
    1. Immunology and Inflammation

    Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

    Eugene Park et al.
    Toxoplasma gondii infection leads to conversion of natural killer cells into cells resembling innate lymphoid cells, group 1, that circulate widely, disrupting current notions suggesting that these cells have distinct lineages.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Subtle selectivity in a pheromone sensor triumvirate desynchronizes competence and predation in a human gut commensal

    Johann Mignolet et al.
    A new cell–cell communication system in Streptococcus salivarius, a human gut commensal, discriminates between close signaling molecules to specifically produce bacteriocin-based antimicrobials and disconnects it from foreign DNA acquisition.

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