Sox2 transcription is not correlated with spatial proximity of its essential regulatory enhancer in embryonic stem cells, suggesting gene transcription is not limited to periods of direct enhancer-promoter contact.
Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.
Analysis of zebrafish periderm enhancers illuminates the conserved DNA of epithelial enhancers across species and prioritizes orofacial-cleft-associated regulatory variants near KRT18/KRT8.
Temporal changes in genome-wide enhancer transcription activity during a transdifferentiation event reveal additive and synergistic enhancer cooperation.
An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.
The chromatin remodeler and tumor suppressor SMARCB1 acts to restrict superenhancer function to direct neural differentiation of embryonic stem cells while repressing bivalent gene activity in the pluripotent state.
Transcription-factor-dependent noncoding RNA transcription illuminates components of a transcription-factor-dependent gene regulatory network that includes enhancer-associated long noncoding RNAs and is necessary for cardiac rhythm.
Genetic and epigenetic editing experiments establish causal links between transposon-derived enhancers and gene regulation in mouse embryonic and extraembryonic lineages.
