1,791 results found
    1. Neuroscience

    Selective increases in inter-individual variability in response to environmental enrichment in female mice

    Julia C Körholz et al.
    The classical experimental paradigm of "enriched environments" is repositioned as a tool to address the question of how behavioral activity and the environment contribute to specific differences between individuals.
    1. Neuroscience

    Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice

    Hongsheng Zhang et al.
    Enriched environment stimulates neuron generation in the hippocampus by a novel pathway involving Agrin, Lrp4, and Ror2.
    1. Neuroscience

    Defective memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome

    Jie Li et al.
    Activity-dependent genetic labeling during behavioral learning shows Fragile-X syndrome model mice exhibit impaired hippocampal engram reactivation, and that enriched environment experience improves fear memory retrieval by enhancing engram reactivation efficacy.
    1. Neuroscience

    Environmental stimuli shape microglial plasticity in glioma

    Stefano Garofalo et al.
    The microenvironment of brain tumors can be modulated by in vivo conditions that change the brain levels of BDNF and IL-15, with effects on innate immune cell activation.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Point of View: Looking back and looking forward at Janelia

    Gerald M Rubin, Erin K O'Shea
    The Janelia Research Campus opened its doors 12 years ago: we describe the philosophy underpinning Janelia, the lessons learned, and plans for the future.
    1. Cancer Biology

    Philosophy of Biology: Characterizing causality in cancer

    Elena Rondeau et al.
    Ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body.
  1. Point of View: Unbridle biomedical research from the laboratory cage

    Garet P Lahvis
    Recent advances in technology now make it possible to carry out biomedical research on animals living in the wild, or captive animals living in naturalistic conditions.
    1. Neuroscience

    Social Neuroscience: How does social enrichment produce health benefits?

    Takefumi Kikusui
    Oxytocin appears to link social interaction and cell aging in rats, especially in females.
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