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    1. Microbiology and Infectious Disease

    Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

    Zikai Zhao, Qi Li ... Jing Ye
    Zika virus infection induces the gasdermin E-mediated pyroptosis in placental cells through TNF-α-caspase-8-caspase-3 signaling pathway, which contributes to adverse fetal outcomes in pregnant mouse model.
    1. Cell Biology
    2. Genetics and Genomics

    Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

    David W Morgens, Charlene Chan ... Michael C Bassik
    Using a suite of CRISPR technologies, unique chemical tools, and carefully designed biochemical and cell biological assays, we define the mechanism of action of Retro-2, an inhibitor of retrograde toxins.
    1. Microbiology and Infectious Disease

    Evidence of human infection by a new mammarenavirus endemic to Southeastern Asia

    Kim R Blasdell, Veasna Duong ... Philippe Buchy
    New mammarenaviruses have been identified from rodents in Cambodia and Thailand, and the Cardamones variant of Wēnzhōu virus has been found in Cambodian patients presenting with fever and respiratory symptoms.
    1. Structural Biology and Molecular Biophysics
    2. Physics of Living Systems

    Architecture of the chikungunya virus replication organelle

    Timothée Laurent, Pravin Kumar ... Lars-Anders Carlson
    The combination of cellular cryo-electron tomography, biochemistry, and mathematical modeling provides the first integrated structural model of the Alphavirus replication organelle.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Guanidine hydrochloride reactivates an ancient septin hetero-oligomer assembly pathway in budding yeast

    Courtney R Johnson, Marc G Steingesser ... Michael A McMurray
    A naturally-occurring small molecule acts as a chemical chaperone in vivo to alter the folding of a budding yeast septin and promote an oligomerization pathway that was lost during evolution.
    1. Cancer Biology
    2. Cell Biology

    Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

    Zijing Wang, Bihan Xia ... Jilin Yang
    The inhibition of colorectal cancer (CRC) proliferation, migration, and invasion is attributed to BEST4, which exhibits epistasis over Hes4 in the downregulation of Twist1 and consequent suppression of epithelial-to-mesenchymal transition in CRC.
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