1,286 results found
    1. Cell Biology

    The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

    Philipp Kimmig, Marcy Diaz ... Peter Walter
    A unique form of regulation has been observed in the unfolded protein response of S. pombe, along with a novel mechanism of post-transcriptional mRNA processing.
    1. Cell Biology

    A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

    Rosanna A Alegado, Laura W Brown ... Nicole King
    The development of colonies of cells in choanoflagellates, water-dwelling organisms that feed on bacteria, is triggered by the presence of very low concentrations of a lipid molecule produced by certain types of bacteria.
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of human polycomb repressive complex 2

    Claudio Ciferri, Gabriel C Lander ... Eva Nogales
    Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.
    1. Neuroscience

    The activity-dependent histone variant H2BE modulates the life span of olfactory neurons

    Stephen W Santoro, Catherine Dulac
    A genome-organizing protein that is present only in the olfactory system of mice has been found to orchestrate changes in the relative numbers of different odor-sensing neurons on the basis of how active these neurons are.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Anca M Farcas, Neil P Blackledge ... Robert J Klose
    A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates

    Tijana Ivanovic, Jason L Choi ... Stephen C Harrison
    Long-lived intermediate states formed by glycoprotein catalysts are an essential part of the process used by influenza virus particles to infect cells.
    1. Neuroscience

    Convergence of pontine and proprioceptive streams onto multimodal cerebellar granule cells

    Cheng-Chiu Huang, Ken Sugino ... Adam W Hantman
    Individual granule cells within the cerebellum-the region of the brain that coordinates movement and supports the learning of new motor skills-receive both sensory and motor input streams: an arrangement that may help the brain to use feedback to fine-tune movement.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors

    Kasper R Andersen, Evgeny Onischenko ... Thomas U Schwartz
    Components of the nuclear pore complex share structural and functional features with soluble nuclear transport receptors, which suggests that there may be an evolutionary relationship between these two types of protein.
    1. Structural Biology and Molecular Biophysics

    Viral genome structures are optimal for capsid assembly

    Jason D Perlmutter, Cong Qiao, Michael F Hagan
    Computer simulations reveal that viral nucleic acids have an ideal structure for being packaged into outer protein shells called capsids.

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