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    1. Microbiology and Infectious Disease

    Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

    Jennifer L Elliott, Jenna E Eschbach ... Sebla B Kutluay
    HIV-1 integrase-RNA interactions account for the key role of integrase in particle maturation.
    1. Structural Biology and Molecular Biophysics

    Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

    David Yin-wei Lin, Lauren E Kueffer ... Amy H Andreotti
    Multiple dynamic protein interactions converge to regulate the catalytic activity of the B cell kinase, BTK.
    1. Developmental Biology

    Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina

    Rana Amini, Archit Bhatnagar ... Caren Norden
    Horizontal cell undergoes amoeboid-like migration in the developing vertebrate retina, a not previously reported migration mode in the central nervous system, that allows them to move within a densely packed tissue without predetermined paths.
    1. Cell Biology

    SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation

    Mohsen Sarikhani, Sneha Mishra ... Nagalingam R Sundaresan
    Mass spectroscopy, molecular modeling and/or molecular dynamics simulations reveal how acetylation regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation.
    1. Developmental Biology
    2. Physics of Living Systems

    Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early Caenorhabditis elegans development

    Lokesh G Pimpale, Teije C Middelkoop ... Stephan W Grill
    Developmentally controlled chiral counter-rotating actomyosin flows drive cell-lineage spindle skews and cell rearrangements during cytokinesis in early nematode development.
    1. Genetics and Genomics

    ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair

    Daniel Wells, Emmanuelle Bitoun ... Simon R Myers
    ZCWPW1 has co-evolved with PRDM9, in particular the PRDM9-SET domain, and although not involved in PRDM9's role in positioning recombination events, it is required for PRDM9's role in pairing chromosomes.
    1. Structural Biology and Molecular Biophysics

    Residue proximity information and protein model discrimination using saturation-suppressor mutagenesis

    Anusmita Sahoo, Shruti Khare ... Raghavan Varadarajan
    Experimental determination of residue contacts from mutational data allows model discrimination and identification of in vivo functional conformations of proteins.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A conserved cell-pole determinant organizes proper polar flagellum formation

    Erick E Arroyo-Pérez, John C Hook ... Simon Ringgaard
    FipA is a novel component required for bacteria that rely on FlhF/FlhG to properly localize their flagella to the cell pole.
    1. Structural Biology and Molecular Biophysics

    Novel sterol binding domains in bacteria

    Liting Zhai, Amber C Bonds ... Laura MK Dassama
    A combination of bioinformatics, protein biochemistry, and X-ray crystal structures reveals new bacterial proteins that are capable of binding to sterols.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    CaMKII autophosphorylation can occur between holoenzymes without subunit exchange

    Iva Lučić, Léonie Héluin ... Andrew JR Plested
    CaMKII is capable of spreading activity between holoenzymes without exchanging subunits.