1,220 results found
    1. Microbiology and Infectious Disease

    Cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

    Junghoon Lee, Scot P Ouellette
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Cancer Biology

    Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

    Jessica Armand, Sungsoo Kim ... Hee Won Yang
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Discriminating neural ensemble patterns through dendritic computations in randomly connected feedforward networks

    Bhanu Priya Somashekar, Upinder Singh Bhalla
    In feedforward networks with random connectivity, connection motifs underlying the detection of short clusters and activity sequences are likely to converge on a subset of postsynaptic neurons purely by chance.
    1. Biochemistry and Chemical Biology

    Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

    Gabriella O Estevam, Edmond M Linossi ... James S Fraser
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology

    Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis

    Jingjing Li, Xinyue Wang ... Vincent Archambault
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience

    Auditory perception and neural representation of temporal fine structure are impaired by age but not by cochlear synaptopathy

    Friederike Steenken, Rainer Beutelmann ... Georg M Klump
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Microbiology and Infectious Disease

    Artesunate, EDTA and colistin work synergistically against MCR-negative and -positive colistin-resistant Salmonella

    Yajun Zhai, Peiyi Liu ... Yajun Zhai
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    ATP burst is the dominant driver of antibiotic lethality in Mycobacterium smegmatis

    Tejan Lodhiya, Aseem Palande ... Raju Mukherjee
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

    Patsy R Tomlinson, Rachel G Knox ... Robert K Semple
    PIK3R1 mutations that cause immunodeficiency through PI3-kinase hyperactivation also cause SHORT syndrome, due to PI3-kinase hypofunction, attributable to PI3-kinase destabilisation and outcompetition by mutant PIK3R1.
    1. Microbiology and Infectious Disease

    Wag31, a membrane tether, is crucial for lipid homeostasis in mycobacteria

    Yogita Kapoor, Himani Khurana ... Vinay Kumar Nandicoori
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
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