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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease

    Ana J Caetano et al.
    Single cell transcriptomic analysis provides a reference map for human oral muscosa in health and disease and a framework for the development of new therapeutic strategies.
    1. Cancer Biology

    Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

    Richard Lee Barrett, Ellen Puré
    Long under-appreciated, fibroblast biology is a key aspect of understanding how the immune system responds to tumors and may hold the key to improving immunotherapy in this tricky space.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

    Steffen Preissler et al.
    Regulation of the endoplasmic reticulum chaperone BiP by calcium.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cardiac endothelial cells maintain open chromatin and expression of cardiomyocyte myofibrillar genes

    Nora Yucel et al.
    Endothelial cells in the heart have transcriptional and epigenetic signatures of cardiomyocytes.
    1. Ecology
    2. Genetics and Genomics

    Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks

    Beryl M Jones et al.
    Integration of automatic behavioral tracking with brain molecular profiling reveals the role of gene regulatory network plasticity in the regulation of behavioral phenotypes.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

    Ilona Rissanen et al.
    An integrated cryoEM and X-ray crystallography study resolves the structural basis for antibody-mediated targeting of the hantavirus fusion glycoprotein and provides insight into the conformational landscape of the hantavirion surface.
    1. Neuroscience

    Central processing of leg proprioception in Drosophila

    Sweta Agrawal et al.
    Proprioceptive signals about leg position, movement, and vibration are integrated in downstream circuits in the fly's central nervous system.
    1. Medicine

    The role of extracellular matrix phosphorylation on energy dissipation in bone

    Stacyann Bailey et al.
    Global extracellular bone matrix phosphorylation level is optimized for appropriate mechanical function and is affected by the presence and heterogeneity in phosphorylation of osteopontin.
    1. Cell Biology
    2. Developmental Biology

    The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans

    Clemens Heissenberger et al.
    In nematode worms, NSUN-1 methylates ribosomal RNA and influences phenotypes related to aging, stress resistance, germ line development, and cuticle integrity by regulating translation of specific mRNAs.
    1. Cell Biology

    Translation in amino-acid-poor environments is limited by tRNAGln charging

    Natalya N Pavlova et al.
    Amino acid limitation triggers preferential uncharging of glutamine-specific tRNAs and depletes polyglutamine tract-containing proteins from mammalian cells, revealing a potential role for polyglutamine tracts as sensors of glutamine sufficiency.